脂质组学分析揭示了被动吸烟对女性面部皮肤表面脂质的影响

IF 3.4 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Mengzhen Zhao , Keliang Fan , Jia Wang , Juan Wang , Qingqing Xu , Dandan Wei , Yuanyuan Chen , Lihong Zhou , Zhenxing Mao , Tian Chen
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引用次数: 1

摘要

吸烟对皮肤有毒害作用,会损害皮肤。然而,很少有研究关注被动吸烟对面部皮肤表面脂质(SSL)的影响。方法采用横断面分析方法,对自愿参与研究的中国河南省中年女性进行研究。本研究共招募了20名被动吸烟女性和20名非被动吸烟女性。采用超高效液相色谱-四极杆飞行时间质谱法(UPLC-QTOF-MS)测定皮肤表面脂质成分。采用多变量数据分析和富集分析探讨了被动吸烟和非被动吸烟女性面部SSL的差异。结果被动吸烟和非被动吸烟女性面部SSL共鉴定出1247个脂质实体。两组面部SSL的组成差异有统计学意义。经多变量数据分析,鉴定出28种具有显著差异的脂质,并将其分为4类。在女性额头的SSL中还获得了32种显著不同的脂质,包括3类脂质。随后的分析显示,与对照组相比,被动吸烟女性的脂肪酸(FA)含量显著降低,甘油脂(GL)和鞘脂(SP)含量升高。结论女性被动吸烟患者面部脂质GLs和SPs升高,FAs降低。脂质的这些变化可能与氧化应激和烟雾中物质对信号通路的干扰有关。被动吸烟影响面部SSL,改变皮肤脂质含量和代谢。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lipidomic analysis reveals the effect of passive smoking on facial skin surface lipid in females

Background

Smoking has toxic effects on the skin and can damage it. However, few studies have focused on the lipid profile changes of facial skin surface lipids (SSL) by passive smoking.

Method

A cross-sectional analytical study was conducted on middle-aged females volunteered from Henan, China to participate in the study. A total of 20 passive smoking females and 20 non-passive smoking females were recruited for this study. The components of skin surface lipids were measured by ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-QTOF-MS). Multivariate data analysis and enrichment analysis were used to investigate the differences in facial SSL between passive and non-passive smoking females.

Result

There were 1247 lipid entities identified in facial SSL between passive and non-passive smoking females. Significant differences in composition of facial SSL were observed between the two groups. After multivariate data analysis suggested, 28 significantly different lipids were identified and classified into four classes in SSL of the female cheeks. As well as 32 significantly different lipids were obtained in SSL of the female foreheads, which included three classes of lipids. Subsequent analysis revealed that the content of fatty acids (FA) in passive smoking females was significantly reduced and the content of glycerolipids (GL) and sphingolipids (SP) increased, compared with the control group.

Conclusion

These results indicated that an increase in GLs and SPs of facial lipids and a decrease in FAs in passive smoking females. These changes in lipids might be associated with oxidative stress and interference with signaling pathways by substances in smoke. And passive smoking affected facial SSL and changed the content and metabolism of skin lipids.

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来源期刊
Chemistry and Physics of Lipids
Chemistry and Physics of Lipids 生物-生化与分子生物学
CiteScore
7.60
自引率
2.90%
发文量
50
审稿时长
40 days
期刊介绍: Chemistry and Physics of Lipids publishes research papers and review articles on chemical and physical aspects of lipids with primary emphasis on the relationship of these properties to biological functions and to biomedical applications. Accordingly, the journal covers: advances in synthetic and analytical lipid methodology; mass-spectrometry of lipids; chemical and physical characterisation of isolated structures; thermodynamics, phase behaviour, topology and dynamics of lipid assemblies; physicochemical studies into lipid-lipid and lipid-protein interactions in lipoproteins and in natural and model membranes; movement of lipids within, across and between membranes; intracellular lipid transfer; structure-function relationships and the nature of lipid-derived second messengers; chemical, physical and functional alterations of lipids induced by free radicals; enzymatic and non-enzymatic mechanisms of lipid peroxidation in cells, tissues, biofluids; oxidative lipidomics; and the role of lipids in the regulation of membrane-dependent biological processes.
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