巨噬细胞极化、代谢重编程和缺血性心脏病的炎症作用。

IF 8.3 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
ACS Applied Materials & Interfaces Pub Date : 2022-07-18 eCollection Date: 2022-01-01 DOI:10.3389/fimmu.2022.934040
Xiaoqian Sun, Yanqin Li, Qiong Deng, Yueyao Hu, Jianteng Dong, Wei Wang, Yong Wang, Chun Li
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引用次数: 5

摘要

巨噬细胞是高度可塑性的细胞,代表其功能焦点的极化激活行为与代谢重编程密切相关。巨噬细胞的代谢重编程表现为对能量利用的偏好,通过改变它们使用能量的方式来改变它们的炎症表型。代谢重编程效应与炎症作用的生物学过程相互作用,是巨噬细胞炎症功能的关键。在缺血性心脏病中,循环募集和组织驻留巨噬细胞的表型极化和代谢变化可以影响心脏炎症作用的平衡,并决定疾病的消退和预后。在这篇综述中,我们提出巨噬细胞极化与代谢重编程之间的内在联系,讨论了在缺血性心脏病炎症作用中调节巨噬细胞的因素。我们的目标是建立可靠的调控途径,使我们能够更好地靶向巨噬细胞代谢重编程过程,改善缺血性心脏病的症状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Macrophage Polarization, Metabolic Reprogramming, and Inflammatory Effects in Ischemic Heart Disease.

Macrophage Polarization, Metabolic Reprogramming, and Inflammatory Effects in Ischemic Heart Disease.

Macrophages are highly plastic cells, and the polarization-activating actions that represent their functional focus are closely related to metabolic reprogramming. The metabolic reprogramming of macrophages manifests itself as a bias toward energy utilization, transforming their inflammatory phenotype by changing how they use energy. Metabolic reprogramming effects crosstalk with the biological processes of inflammatory action and are key to the inflammatory function of macrophages. In ischemic heart disease, phenotypic polarization and metabolic shifts in circulating recruitment and tissue-resident macrophages can influence the balance of inflammatory effects in the heart and determine disease regression and prognosis. In this review, we present the intrinsic link between macrophage polarization and metabolic reprogramming, discussing the factors that regulate macrophages in the inflammatory effects of ischemic heart disease. Our aim is to estabilsh reliable regulatory pathways that will allow us to better target the macrophage metabolic reprogramming process and improve the symptoms of ischemic heart disease.

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来源期刊
ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces 工程技术-材料科学:综合
CiteScore
16.00
自引率
6.30%
发文量
4978
审稿时长
1.8 months
期刊介绍: ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
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