印度东部成人疟疾合并感染的结果。

IF 1 Q4 INFECTIOUS DISEASES
Journal of Global Infectious Diseases Pub Date : 2022-06-29 eCollection Date: 2022-04-01 DOI:10.4103/jgid.jgid_279_21
Saurabh Pandey, Priyanka Rai, Subhasish Kamal Guha, Ardhendu Maji, Subir Ghosh, Prantiki Halder, Manoj Kumar Gupta, Soumen Nath Halder, Dolanchampa Modak
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引用次数: 1

摘要

导言:由于在疟疾患者中诊断检测的可获得性和利用率提高,与细菌、病毒和立克次体等不同病原体的共同感染正日益得到认识。方法:选取连续住院的疟疾病例,对其进行一般调查、细菌、伤寒、登革热、基孔肯雅热检查和特殊诊断休息。所有患者均随访至出院或死亡,并进行相应的统计学检验。结果:共纳入152例疟疾患者,并发感染27例(18.8%)。其中仅登革热40.7%,肺炎18.7%,尿路感染11.1%,肠热7.4%,钩端螺旋体病、基孔肯雅病和结核性脑膜炎3.7%,登革热合并肺炎和尿路感染各3.7%。分离出的微生物有肺炎链球菌、肺炎克雷伯菌、大肠杆菌、伤寒沙门氏菌和结核分枝杆菌。平均发热时间为6.33±3.63 d,范围为3 ~ 20 d。2例斑疹伤寒沙门氏菌和肺炎克雷伯菌血培养生长;登革合并感染具有明显更高的登革热临床和实验室特征以及并发症,如出血、黄疸和胆囊炎,而其余并发感染具有明显更高比例的恶心和呕吐、抽搐、感觉改变、咳痰、泌尿系统症状、休克、急性肾损伤、贫血和平均中性粒细胞计数。疟疾-登革热并发感染2组的死亡率(15.4%)明显高于疟疾单感染3组(2.4%)。结论:疟疾合并感染并不罕见,尤其是登革热和其他细菌感染。主要临床表现为叠加感染。决策应在临床指导下,配合具体的诊断检查,及时治疗有良好的效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Outcome of Adult Malarial Co-infections in Eastern India.

Outcome of Adult Malarial Co-infections in Eastern India.

Outcome of Adult Malarial Co-infections in Eastern India.

Introduction: Co-infection with different agents such as bacterial, viral, and Rickettsia is being increasingly recognized due to greater availability and utilization of the diagnostic tests among malaria patients.

Methods: Consecutive admitted malarial cases were included and were subjected to test for general investigations, bacteria, typhoid, dengue, chikungunya, and rest for specific diagnosis. All patients were followed up till discharge or death and appropriate statistical tests were performed.

Results: A total of 152 malaria patients were recruited and 27 (18.8%) had concurrent infections. It included 40.7% dengue only, 18.7% pneumonia, 11.1% urinary tract infection (UTI), 7.4% enteric fever, 3.7% leptospirosis, chikungunya, and tuberculous meningitis each, and 3.7% each of dengue with pneumonia and UTI. The organisms isolated were Streptococcus pneumoniae, Klebsiella pneumoniae, Escherichia coli, Salmonella typhi, and Mycobacterium tuberculosis. The mean duration of fever was 6.33 ± 3.63 days with a range of 3-20 days. Blood culture grew in 2 cases S. typhi and K. pneumonia,e. Dengue co-infections had significantly higher clinical and laboratory features of dengue and complications such as bleeding, jaundice, and cholecystitis, whereas rest concurrent infections had a significantly higher proportion of nausea and vomiting, convulsion, altered sensorium, productive cough, urinary symptoms, shock, acute kidney injury, anemia, and mean neutrophil count. There was significantly higher mortality among malaria-dengue concurrent infection group with 2 (15.4%) than malaria mono-infection group 3 (2.4%).

Conclusion: Co-infections with malaria are not uncommon, especially dengue fever and other bacterial infections. The dominant clinical picture is of the superimposed infection. Decision should be clinically guided adjunct with specific diagnostic tests, and timely treatment has favorable outcome.

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来源期刊
CiteScore
3.30
自引率
0.00%
发文量
31
审稿时长
29 weeks
期刊介绍: JGID encourages research, education and dissemination of knowledge in the field of Infectious Diseases across the world thus promoting translational research by striking a synergy between basic science, clinical medicine and public health. The Journal intends to bring together scientists and academicians in Infectious Diseases to promote translational synergy between Laboratory Science, Clinical Medicine and Public Health. The Journal invites Original Articles, Clinical Investigations, Epidemiological Analysis, Data Protocols, Case Reports, Clinical Photographs, review articles and special commentaries. Students, Residents, Academicians, Public Health experts and scientists are all encouraged to be a part of this initiative by contributing, reviewing and promoting scientific works and science.
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