原发性闭经与性别发展差异。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-03-01 Epub Date: 2022-06-30 DOI:10.1055/s-0042-1753551

Swetha Naroji, Veronica Gomez-Lobo, Courtney Finlayson

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引用次数: 0

摘要

原发性闭经可能是性别发育差异的特征或表现，最常见的原因是先天性解剖差异或性腺功能低下。病史和体格检查非常重要，包括出生时外生殖器是否存在变异，以及仔细检查青春期发育情况。进一步的评估包括激素测量、影像学检查和遗传学评估。被诊断为性发育障碍的患者应接受多学科团队的治疗和社会心理支持。

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Primary Amenorrhea and Differences of Sex Development.

Primary amenorrhea may be a feature or a presenting sign of a difference of sex development, most often due to a congenital anatomic difference or hypergonadotropic hypogonadism. History and physical exam are very important, including whether any variation in external genitalia was present at birth as well as a careful review of pubertal development. Further evaluation includes hormone measurement, imaging, and genetic evaluation. Those with a disorder of sexual development diagnosis should receive care through a multidisciplinary team with psychosocial support.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.