肾移植术后多瘤病毒、巨细胞病毒和病毒合并感染的危险因素分析。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Ho Trung Hieu, Bui Tien Sy
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引用次数: 1

摘要

背景:病毒感染的相互作用可能与肾移植术后发病率增加有关。本研究旨在确定肾移植受者病毒感染的发生率和危险因素。材料和方法在这项纵向研究中,纳入了2019年1月至2021年12月在越南一家医院记录的81例肾移植患者的502次发作。检测BK、JC多瘤病毒、CMV、EBV、HSV。采用多变量Cox回归分析评价病毒感染的危险因素。结果合并病毒感染56例(69.1%)。JC、CMV和BK感染是最常见的病毒,分别占67.9%、61.7%和56.8%。Cox回归分析显示,单次感染、MMF剂量(HR 1.002)、皮质激素(HR 1.02)、高血压(HR 1.65)、血尿(HR 2.03)是发生JC的危险因素;CMV感染的危险因素为男性(HR 1.92)和eGFR (HR 0.98);BK单次感染的危险因素为高血压(HR 1.67)、蛋白尿(HR 3.80)、他克莫司谷值较高(HR 1.17)和MMF剂量(HR 1.002)。高血压(HR 1.68)、空腹血糖(HR 1.13)、蛋白尿(HR 6.01)、他克莫司低谷水平(HR 1.12)、MMF剂量(HR 1.004)是病毒合并感染的独立危险因素。结论肾功能与病毒尿的发生率相关。MMF的高他克莫司谷水平和剂量与BK、JC和合并感染的高风险相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Risk Factors for Polyomavirus, Cytomegalovirus, and Viruria Co-Infection for Follow-Up of Renal Transplant Patients.

Risk Factors for Polyomavirus, Cytomegalovirus, and Viruria Co-Infection for Follow-Up of Renal Transplant Patients.

Risk Factors for Polyomavirus, Cytomegalovirus, and Viruria Co-Infection for Follow-Up of Renal Transplant Patients.

Risk Factors for Polyomavirus, Cytomegalovirus, and Viruria Co-Infection for Follow-Up of Renal Transplant Patients.

BACKGROUND The interaction of viral infection may be associated with increased morbidity after renal transplantation. This study aimed to identify the incidence and risk factors of viruria infections in renal transplant recipients. MATERIAL AND METHODS In this longitudinal study, 502 episodes recorded in 81 kidney transplant patients from 1/2019 to 12/2021 in a hospital in Vietnam were included. BK, JC polyomaviruses, CMV, EBV, and HSV were detected. Multivariable Cox regression analysis was performed to evaluate risk factors for the viruria infection. RESULTS Fifty-six patients (69.1%) had viruria co-infection. The incidence of JC, CMV, and BK infection was the most common viruria, with 67.9%, 61.7%, and 56.8%, respectively. Cox regression revealed that the risk factors for JC were single infection, dose of MMF (HR 1.002), corticoid (HR 1.02), hypertension (HR 1.65), and hematuria (HR 2.03); risk factors for CMV infection were male sex (HR 1.92) and eGFR (HR 0.98); risk factors for BK single infection were hypertension (HR 1.67), proteinuria (HR 3.80), higher tacrolimus trough level (HR 1.17), and dose of MMF (HR 1.002). Hypertension (HR 1.68), fasting plasma glucose (HR 1.13), proteinuria (HR 6.01), tacrolimus trough level (HR 1.12), and dose of MMF (HR 1.004) were independent risk factors for the viruria co-infection. CONCLUSIONS Kidney function was associated with the incidence of viruria. Higher tacrolimus trough level and dose of MMF were associated with higher risk of BK, JC, and co-infection.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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