Qin Tang, Fei Xu, Chuanli Zhang, Chang Li, Feng Liu, Ming Shen, Xun Liu, Jiaqi Lin, Limin Zhu, Tingting Lin, Di Sun
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Two birds, one stone: host-guest complex of indocyanine green–β-cyclodextrin for fundus angiography
Indocyanine green (ICG) angiography is of great importance for ophthalmic diagnostic applications and is mainly used to check for choroidal vascular diseases. However, ICG fluorescence imaging probes aggregate in water because they have sulfonyl groups and can form dimers and oligomers. This effect thus reduces the fluorescence of the probes. Therefore, we have established a simple and effective way to prepare β-cyclodextrinmodified ICG (ICG–β-CD) via the host–guest assembly process. In contrast to ICG, ICG–β-CD avoided solution aggregation. Moreover, it exhibited improved absorption intensity. When used as an angiographic contrast agent for ophthalmic choroid examination and diagnosis in SD rats, the fluorescence imaging effect of ICG–β-CD on retinal and choroidal vessels was better than that of ICG on choroidal vessels. Therefore, ICG–β-CD is expected to achieve a "two birds with one stone" effect.
期刊介绍：
The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites.
The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.
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