握力与呼吸系统疾病死亡率：来自 SHARE 的纵向分析。

IF 10.4 2区医学 Q1 RESPIRATORY SYSTEM

Pulmonology Pub Date : 2024-09-01 DOI:10.1016/j.pulmoe.2022.09.007

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引用次数: 0

摘要

背景：虽然手握力与全因死亡率之间的关系得到了更深入的探讨，但以前没有专门针对手握力与呼吸系统疾病死亡率的研究。本研究的目的是在一个具有代表性的大样本中调查手握力与呼吸系统疾病死亡率之间的关系：方法：来自 27 个欧洲国家和以色列的 50 岁或以上的人参加了这项纵向研究。有关手握力、全因死亡率和呼吸系统疾病死亡率的数据来自欧洲健康、老龄化和退休调查（SHARE）第 1、2、4、5、6 和 7 次调查。我们使用 Fine-Gray sub-distribution 方法估算了呼吸系统疾病死亡率的次危险比 (SHR)，其中包括随时间变化的暴露和协变量，以及作为竞争风险的其他原因导致的死亡率。此外，我们还使用限制性立方样条和估计危险比（HRs）评估了手握力（模拟为连续暴露）与呼吸系统疾病死亡率的剂量-反应关系：研究对象包括 60,883 名男性和 74,904 名女性，他们在研究开始时的平均年龄为 63.6 岁（标准差为 9.7 岁）。在中位数（四分位数间距）为 7.4 年的随访期间，有 565 人（0.4%）死于呼吸系统疾病。在对潜在的混杂因素进行调整后，手握力每增加 1 公斤，呼吸系统疾病死亡率就会降低 6%（SHR，0.94；95%CI，0.92-0.96）。此外，手握力每增加一公斤，呼吸系统疾病的死亡风险就会以剂量反应的方式降低，41公斤（HR，0.49；95%CI，0.26-0.92）或更高的数值具有显著的阈值：结论：较高的握力与较低的呼吸系统疾病死亡率相关。需要进行干预研究，以确定呼吸系统疾病患者的力量训练是否能预防过早死亡。

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Handgrip strength and respiratory disease mortality: Longitudinal analyses from SHARE

Background

While the association between handgrip strength and all-cause mortality is more deeply explored, no previous studies have been specifically focused on handgrip strength and respiratory disease mortality. The purpose of the study was to investigate the association between handgrip strength and respiratory disease mortality in a large representative sample.

Methods

Individuals aged 50 or over from 27 European countries and Israel participated in this longitudinal study. Data on handgrip strength and all-cause and respiratory disease mortality were retrieved from the Survey of Health, Ageing and Retirement in Europe (SHARE) waves 1, 2, 4, 5, 6 and 7. We estimated the sub hazard ratios (SHRs) for respiratory disease mortality using a Fine-Gray sub-distribution method with both time-varying exposure and covariates and mortality due to other causes as competing risk. Furthermore, we assessed dose‐response associations of handgrip strength (modelled as a continuous exposure) with respiratory disease mortality using restricted cubic splines and estimated hazard ratios (HRs).

Results

We included 60,883 men and 74,904 women with a mean age of 63.6 (SD 9.7) years at study entry. During a median (interquartile range) of 7.4 years of follow-up 565 (0.4%) participants died due to respiratory diseases. The increase of 1 single kg of handgrip strength showed a 6% incidence reduction on respiratory disease mortality (SHR, 0.94; 95%CI, 0.92-0.96) after adjusting for potential confounders. Furthermore, each kg increase of handgrip strength reduced respiratory disease mortality risk in a dose-response fashion and a significant threshold for values of 41 kg (HR, 0.49; 95%CI, 0.26-0.92) and higher was identified.

Conclusions

Higher handgrip strength is associated with lower mortality due to respiratory disease. Intervention studies are needed to determine whether strength training in respiratory disease patients can prevent premature mortality.

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来源期刊

Pulmonology Medicine-Pulmonary and Respiratory Medicine

CiteScore

14.30

自引率

5.10%

发文量

159

审稿时长

19 days

期刊介绍： Pulmonology (previously Revista Portuguesa de Pneumologia) is the official journal of the Portuguese Society of Pulmonology (Sociedade Portuguesa de Pneumologia/SPP). The journal publishes 6 issues per year and focuses on respiratory system diseases in adults and clinical research. It accepts various types of articles including peer-reviewed original articles, review articles, editorials, and opinion articles. The journal is published in English and is freely accessible through its website, as well as Medline and other databases. It is indexed in Science Citation Index Expanded, Journal of Citation Reports, Index Medicus/MEDLINE, Scopus, and EMBASE/Excerpta Medica.