动态18F-FDG PET/CT鉴别肺内转移与同步多发原发肺癌的应用

IF 2.2 4区 医学 Q3 BIOCHEMICAL RESEARCH METHODS
Molecular Imaging Pub Date : 2022-06-30 eCollection Date: 2022-01-01 DOI:10.1155/2022/8081299
Weize Lv, Min Yang, Hongcheng Zhong, Xiaojin Wang, Shuai Yang, Lei Bi, Jianzhong Xian, Xiaofeng Pei, Xinghua He, Ying Wang, Zhong Lin, Qingdong Cao, Hongjun Jin, Hong Shan
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引用次数: 4

摘要

鉴别同步多发原发肺癌(sMPLC)与原发性肺癌伴肺内转移(IPM)一直是一个巨大的挑战。我们旨在评估动态18F-FDG PET/CT在肺癌多发结节患者中的临床应用。我们招募了接受动态18F-FDG PET/CT的多发肺结节患者,并根据综合特征分为sMPLC组和IPM组。根据动态扫描拟合的ki值,确定每个患者的SUVmax和对应的两个最大肿瘤的最大直径(dmax)。测定SUVmax/D max和ki /D max在肿瘤间的绝对差异(ΔSUVmax/D max;ΔK i /D max),并评估组间差异。进一步,通过ROC分析评估诊断准确性,并确定各组ΔSUVmax/D max和ΔK i /Dmax之间的相关性。IPM组和sMPLC组的ΔSUVmax/ Dmax无显著差异,但IPM组的ΔK i /Dmax显著高于sMPLC组。ΔK i /D max鉴别sMPLC与IPM的AUC为0.80 (K i临界值= 0.0059,敏感性79%,特异性75%,p < 0.001)。IPM组的ΔSUVmax/D max与ΔK i /D max之间有很好的相关性(Pearson r = 0.91, 95% CI: 0.79-0.96, p < 0.0001), sMPLC组的相关性不高(Pearson r = 0.45, p > 0.05)。动态18F-FDG PET/CT可能是区分sMPLC和IPM的有用工具。基于Patlak图形分析的K i计算在鉴别多发性肺癌结节患者的IPM和sMPLC方面比SUVmax更敏感。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Application of Dynamic <sup>18</sup>F-FDG PET/CT for Distinguishing Intrapulmonary Metastases from Synchronous Multiple Primary Lung Cancer.

Application of Dynamic <sup>18</sup>F-FDG PET/CT for Distinguishing Intrapulmonary Metastases from Synchronous Multiple Primary Lung Cancer.

Application of Dynamic <sup>18</sup>F-FDG PET/CT for Distinguishing Intrapulmonary Metastases from Synchronous Multiple Primary Lung Cancer.

Application of Dynamic 18F-FDG PET/CT for Distinguishing Intrapulmonary Metastases from Synchronous Multiple Primary Lung Cancer.

It has been a big challenge to distinguish synchronous multiple primary lung cancer (sMPLC) from primary lung cancer with intrapulmonary metastases (IPM). We aimed to assess the clinical application of dynamic 18F-FDG PET/CT in patients with multiple lung cancer nodules. We enrolled patients with multiple pulmonary nodules who had undergone dynamic 18F-FDG PET/CT and divided them into sMPLC and IPM groups based on comprehensive features. The SUVmax, fitted K i value based on dynamic scanning, and corresponding maximum diameter (D max) from the two largest tumors were determined in each patient. We determined the absolute between-tumor difference of SUVmax/D max and K i /D max (ΔSUVmax/D max; ΔK i /D max) and assessed the between-group differences. Further, the diagnostic accuracy was evaluated by ROC analysis and the correlation between ΔSUVmax/D max and ΔK i /Dmax from all groups was determined. There was no significant difference for ΔSUVmax/D max between the IPM and sMPLC groups, while the IPM group had a significantly higher ΔK i /Dmax than the sMPLC group. The AUC of ΔK i /D max for differentiating sMPLC from IPM was 0.80 (cut-off value of K i = 0.0059, sensitivity 79%, specificity 75%, p < 0.001). There was a good correlation (Pearson r = 0.91, 95% CI: 0.79-0.96, p < 0.0001) between ΔSUVmax/D max and ΔK i /D max in the IPM group but not in the sMPLC group (Pearson r = 0.45, p > 0.05). Dynamic 18F-FDG PET/CT could be a useful tool for distinguishing sMPLC from IPM. K i calculation based on Patlak graphic analysis could be more sensitive than SUVmax in discriminating IPM from sMPLC in patients with multiple lung cancer nodules.

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来源期刊
Molecular Imaging
Molecular Imaging Biochemistry, Genetics and Molecular Biology-Biotechnology
自引率
3.60%
发文量
21
期刊介绍: Molecular Imaging is a peer-reviewed, open access journal highlighting the breadth of molecular imaging research from basic science to preclinical studies to human applications. This serves both the scientific and clinical communities by disseminating novel results and concepts relevant to the biological study of normal and disease processes in both basic and translational studies ranging from mice to humans.
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