脾脏瞬时弹性成像预测肝移植后的精算存活。

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2022-07-25 eCollection Date: 2022-01-01 DOI:10.21037/tgh-19-343

Kilian Friedrich, Arianeb Mehrabi, Jan Pfeiffenberger, Christian Rupp, Karl Heinz Weiss, Markus Mieth

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引用次数: 1

摘要

背景:脾瞬态弹性成像(TE)与门静脉压力升高有关。肝移植后(LTx)的数据很少。方法:术后3个月，对125例LTx受者行脾TE。结果:脾脏TE平均值为29.4(±6.3;范围:21.6-49.2)kPa。脾TE与发育至持续腹水的时间缩短相关(30例，OR =1.082, 95% CI: 1.034-1.133;P=0.001)，肝肾综合征(8例，OR =1.109, 95% CI: 1.015-1.211;P=0.022)和肝性脑病(16例，OR =1.136, 95% CI: 1.066-1.211;P = 0.000)。在Cox单因素分析中，脾脏TE可作为无肝精算生存率的预测因子(OR =1.114, 95% CI: 1.050-1.182;结论:LTx术后3个月脾TE测量可作为LTx受者生存的可靠预测指标。

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Spleen transient elastography predicts actuarial survival after liver transplantation.

Background: Splenic transient elastography (TE) correlates with increased portal pressure. Little data are available in the post liver transplantation (LTx) setting.

Methods: Three months after LTx, we performed splenic TE in 125 LTx recipients.

Results: Mean splenic TE values were 29.4 (±6.3; range, 21.6-49.2) kPa. Splenic TE correlated with reduced time to development until persistent ascites (30 events, OR =1.082, 95% CI: 1.034-1.133; P=0.001), hepatorenal syndrome (8 events, OR =1.109, 95% CI: 1.015-1.211; P=0.022) and hepatic encephalopathy (16 events, OR =1.136, 95% CI: 1.066-1.211; P=0.000). In Cox univariate analysis, splenic TE served as a predictor of actuarial survival free of liver (OR =1.114, 95% CI: 1.050-1.182; P<0.001) and remained an independent risk factor associated with reduced actuarial survival free of LTx in multivariate analysis (OR =1.103, 95% CI: 1.026-1.186; P=0.008).

Conclusions: Splenic TE measurement at 3 months after LTx serves as a robust predictor of survival in LTx recipients.

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567

期刊介绍： ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/Abstracted： Web of Science SCIE Scopus CAS INSPEC Portico