脾脏瞬时弹性成像预测肝移植后的精算存活。

IF 3 4区医学 Q1 Medicine

Translational gastroenterology and hepatology Pub Date : 2022-07-25 eCollection Date: 2022-01-01 DOI:10.21037/tgh-19-343

Kilian Friedrich, Arianeb Mehrabi, Jan Pfeiffenberger, Christian Rupp, Karl Heinz Weiss, Markus Mieth

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引用次数: 1

摘要

背景:脾瞬态弹性成像(TE)与门静脉压力升高有关。肝移植后(LTx)的数据很少。方法:术后3个月，对125例LTx受者行脾TE。结果:脾脏TE平均值为29.4(±6.3;范围:21.6-49.2)kPa。脾TE与发育至持续腹水的时间缩短相关(30例，OR =1.082, 95% CI: 1.034-1.133;P=0.001)，肝肾综合征(8例，OR =1.109, 95% CI: 1.015-1.211;P=0.022)和肝性脑病(16例，OR =1.136, 95% CI: 1.066-1.211;P = 0.000)。在Cox单因素分析中，脾脏TE可作为无肝精算生存率的预测因子(OR =1.114, 95% CI: 1.050-1.182;结论:LTx术后3个月脾TE测量可作为LTx受者生存的可靠预测指标。

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Spleen transient elastography predicts actuarial survival after liver transplantation.

Background: Splenic transient elastography (TE) correlates with increased portal pressure. Little data are available in the post liver transplantation (LTx) setting.

Methods: Three months after LTx, we performed splenic TE in 125 LTx recipients.

Results: Mean splenic TE values were 29.4 (±6.3; range, 21.6-49.2) kPa. Splenic TE correlated with reduced time to development until persistent ascites (30 events, OR =1.082, 95% CI: 1.034-1.133; P=0.001), hepatorenal syndrome (8 events, OR =1.109, 95% CI: 1.015-1.211; P=0.022) and hepatic encephalopathy (16 events, OR =1.136, 95% CI: 1.066-1.211; P=0.000). In Cox univariate analysis, splenic TE served as a predictor of actuarial survival free of liver (OR =1.114, 95% CI: 1.050-1.182; P<0.001) and remained an independent risk factor associated with reduced actuarial survival free of LTx in multivariate analysis (OR =1.103, 95% CI: 1.026-1.186; P=0.008).

Conclusions: Splenic TE measurement at 3 months after LTx serves as a robust predictor of survival in LTx recipients.

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来源期刊

Translational gastroenterology and hepatology Medicine-Gastroenterology

CiteScore

8.20

自引率

0.00%

发文量

期刊介绍： Translational Gastroenterology and Hepatology (Transl Gastroenterol Hepatol; TGH; Online ISSN 2415-1289) is an open-access, peer-reviewed online journal that focuses on cutting-edge findings in the field of translational research in gastroenterology and hepatology and provides current and practical information on diagnosis, prevention and clinical investigations of gastrointestinal, pancreas, gallbladder and hepatic diseases. Specific areas of interest include, but not limited to, multimodality therapy, biomarkers, imaging, biology, pathology, and technical advances related to gastrointestinal and hepatic diseases. Contributions pertinent to gastroenterology and hepatology are also included from related fields such as nutrition, surgery, public health, human genetics, basic sciences, education, sociology, and nursing.