糖皮质激素受体SGK1、NDRG1在hormone-naïve前列腺癌中的表达及临床病理意义。

IF 1.2 4区 医学 Q3 PATHOLOGY
Medical Molecular Morphology Pub Date : 2022-12-01 Epub Date: 2022-07-21 DOI:10.1007/s00795-022-00332-x
Shuko Hata, Hiroki Shimada, Naomi Sato, Mayu Koshiishi, Kazue Ise, Tomoaki Ogata, Shinichi Yamashita, Akihiro Ito, Hironobu Sasano, Yasuhiro Nakamura
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引用次数: 1

摘要

糖皮质激素受体(GR)参与前列腺癌的生长和进展。糖皮质激素受体β (GRβ)作为GR的抑制剂;然而,它的功能还没有被很好地理解。血清和糖皮质激素调节激酶1 (SGK1)是一种gr应答基因,可磷酸化N-myc下游调节基因1 (NDRG1),并参与癌症的生长和侵袭。然而,GR、GRβ、SGK1和NDRG1在前列腺癌中的表达及其与临床病理和功能意义的关系尚不清楚。分析前列腺癌患者GR、GRβ、SGK1、NDRG1免疫反应性与临床病理变量的关系,探讨其临床意义。在前列腺癌病例中,GR和NDRG1免疫反应性的相对丰度与原发肿瘤分期(pT)呈显著负相关,GR免疫反应性与Ki-67评分呈显著负相关。NDRG1的相对表达状态与GR的相对表达状态有显著相关性,而临床病理参数与GRβ和SGK1的表达均无显著相关性。我们的研究结果表明,GR和NDRG1的表达状态与前列腺癌患者的临床病理特征相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Expression and clinicopathological significance of glucocorticoid receptor, SGK1, and NDRG1 in hormone-naïve prostate carcinoma.

Expression and clinicopathological significance of glucocorticoid receptor, SGK1, and NDRG1 in hormone-naïve prostate carcinoma.

Glucocorticoid receptor (GR) has been implicated in prostate carcinoma growth and progression. Glucocorticoid receptor beta (GRβ) acts as an inhibitor of GR; however, its function is not well understood. Serum- and glucocorticoid-regulated kinase 1 (SGK1) is a GR-responsive gene that phosphorylates N-myc downstream-regulated gene 1 (NDRG1) and is involved in cancer growth and invasion. However, the expression of GR, GRβ, SGK1, and NDRG1 in prostate cancer and their relationship with clinicopathological and functional significance remain unknown. The association between the status of GR, GRβ, SGK1, and NDRG1 immunoreactivity and clinicopathological variables was analyzed in patients with prostate carcinoma to explore their clinical significance. In prostate carcinoma cases, the relative abundance of GR and NDRG1 immunoreactivity was inversely and significantly associated with the primary tumor stage (pT), while GR immunoreactivity was inversely and significantly associated with the Ki-67 score. The relative expression status of NDRG1 was significantly associated with that of GR. However, no significant correlation was observed between any of the clinicopathological parameters and GRβ and SGK1 expression. Our findings indicate that GR and NDRG1 expression status is correlated with clinicopathological features in patients with prostate cancer.

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来源期刊
Medical Molecular Morphology
Medical Molecular Morphology 医学-病理学
CiteScore
2.90
自引率
5.60%
发文量
30
审稿时长
>12 weeks
期刊介绍: Medical Molecular Morphology is an international forum for researchers in both basic and clinical medicine to present and discuss new research on the structural mechanisms and the processes of health and disease at the molecular level. The structures of molecules, organelles, cells, tissues, and organs determine their normal function. Disease is thus best understood in terms of structural changes in these different levels of biological organization, especially in molecules and molecular interactions as well as the cellular localization of chemical components. Medical Molecular Morphology welcomes articles on basic or clinical research in the fields of cell biology, molecular biology, and medical, veterinary, and dental sciences using techniques for structural research such as electron microscopy, confocal laser scanning microscopy, enzyme histochemistry, immunohistochemistry, radioautography, X-ray microanalysis, and in situ hybridization. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.
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