Letizia Nitro, Antonio Mario Bulfamante, Cecilia Rosso, Alberto Maria Saibene, Flavio Arnone, Giovanni Felisati, Carlotta Pipolo
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Adverse effects of dupilumab in chronic rhinosinusitis with nasal polyps. Case report and narrative review.
SUMMARY Herein we review the current literature on the adverse effects related to biological therapy with the monoclonal antibody dupilumab in patients with type 2 inflammation prevalent phenotype chronic rhinosinusitis with nasal polyps (CRSwNP). Our review shows that the side effects of dupilumab may be linked to the prevalent type 2 inflammation phenotype (asthma, dermatitis, CRSwNP). We also report the first case of cutaneous rash as a side effect of dupilumab in a patient with CRSwNP.
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