{"title":"关键问题:微生物、记忆和耐药性","authors":"Adam Dickinson","doi":"10.1016/j.endeavour.2022.100821","DOIUrl":null,"url":null,"abstract":"<div><p>Horizontal Gene Transfer (HGT) is a key mechanism allowing bacteria to enact genetic changes in response to shifting environmental conditions. The swift lateral movement of genes makes possible antibiotic resistance, which is an increasing medical and ultimately cultural problem. There is evidence that HGT also takes place between species. Bacterial DNA appears in the human mitochondrial genome of acute myeloid leukemia (AML) samples. Responding to a recent diagnosis of AML, this creative piece imagines a literary form of HGT. Adjacency is intrinsic to the conceptual and formal concerns of the text. Moving back and forth between essay and poem, between the personal and the planetary, between the real and the imagined, and between the right and left margins of the page, this piece unfolds beside itself, exploring the lateral movement of memory and family history through concerns with antibiotic resistance, illness, writing, and science. While there are no embedded citations or footnotes, a glossary of terms (Appendix 1) follows the main text, and a brief bibliographic essay (Appendix 2) at the end identifies cited sources that correspond to a list of references.</p></div>","PeriodicalId":51032,"journal":{"name":"Endeavour","volume":"46 1","pages":"Article 100821"},"PeriodicalIF":0.5000,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Neck of the woods: Microbes, memory, and resistance\",\"authors\":\"Adam Dickinson\",\"doi\":\"10.1016/j.endeavour.2022.100821\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Horizontal Gene Transfer (HGT) is a key mechanism allowing bacteria to enact genetic changes in response to shifting environmental conditions. The swift lateral movement of genes makes possible antibiotic resistance, which is an increasing medical and ultimately cultural problem. There is evidence that HGT also takes place between species. Bacterial DNA appears in the human mitochondrial genome of acute myeloid leukemia (AML) samples. Responding to a recent diagnosis of AML, this creative piece imagines a literary form of HGT. Adjacency is intrinsic to the conceptual and formal concerns of the text. Moving back and forth between essay and poem, between the personal and the planetary, between the real and the imagined, and between the right and left margins of the page, this piece unfolds beside itself, exploring the lateral movement of memory and family history through concerns with antibiotic resistance, illness, writing, and science. While there are no embedded citations or footnotes, a glossary of terms (Appendix 1) follows the main text, and a brief bibliographic essay (Appendix 2) at the end identifies cited sources that correspond to a list of references.</p></div>\",\"PeriodicalId\":51032,\"journal\":{\"name\":\"Endeavour\",\"volume\":\"46 1\",\"pages\":\"Article 100821\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2022-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endeavour\",\"FirstCategoryId\":\"98\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0160932722000217\",\"RegionNum\":4,\"RegionCategory\":\"哲学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"HISTORY & PHILOSOPHY OF SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endeavour","FirstCategoryId":"98","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0160932722000217","RegionNum":4,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"HISTORY & PHILOSOPHY OF SCIENCE","Score":null,"Total":0}
Neck of the woods: Microbes, memory, and resistance
Horizontal Gene Transfer (HGT) is a key mechanism allowing bacteria to enact genetic changes in response to shifting environmental conditions. The swift lateral movement of genes makes possible antibiotic resistance, which is an increasing medical and ultimately cultural problem. There is evidence that HGT also takes place between species. Bacterial DNA appears in the human mitochondrial genome of acute myeloid leukemia (AML) samples. Responding to a recent diagnosis of AML, this creative piece imagines a literary form of HGT. Adjacency is intrinsic to the conceptual and formal concerns of the text. Moving back and forth between essay and poem, between the personal and the planetary, between the real and the imagined, and between the right and left margins of the page, this piece unfolds beside itself, exploring the lateral movement of memory and family history through concerns with antibiotic resistance, illness, writing, and science. While there are no embedded citations or footnotes, a glossary of terms (Appendix 1) follows the main text, and a brief bibliographic essay (Appendix 2) at the end identifies cited sources that correspond to a list of references.
期刊介绍:
Endeavour, established in 1942, has, over its long and proud history, developed into one of the leading journals in the history and philosophy of science. Endeavour publishes high-quality articles on a wide array of scientific topics from ancient to modern, across all disciplines. It serves as a critical forum for the interdisciplinary exploration and evaluation of natural knowledge and its development throughout history. Each issue contains lavish color and black-and-white illustrations. This makes Endeavour an ideal destination for history and philosophy of science articles with a strong visual component.
Endeavour presents the history and philosophy of science in a clear and accessible manner, ensuring the journal is a valuable tool for historians, philosophers, practicing scientists, and general readers. To enable it to have the broadest coverage possible, Endeavour features four types of articles:
-Research articles are concise, fully referenced, and beautifully illustrated with high quality reproductions of the most important source material.
-In Vivo articles will illustrate the rich and numerous connections between historical and philosophical scholarship and matters of current public interest, and provide rich, readable explanations of important current events from historical and philosophical perspectives.
-Book Reviews and Commentaries provide a picture of the rapidly growing history of science discipline. Written by both established and emerging scholars, our reviews provide a vibrant overview of the latest publications and media in the history and philosophy of science.
-Lost and Found Pieces are playful and creative short essays which focus on objects, theories, tools, and methods that have been significant to science but underappreciated by collective memory.