通常的转氨酶值:是否需要重新检查和调整?

IF 0.4 4区 医学 Q4 MEDICAL LABORATORY TECHNOLOGY
Alexandre Raynor, Anna Soavelomandroso, Tiphaine Robert-Mercier, Dominique Valla, Katell Peoc'h, Célia Raulet-Bussian
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引用次数: 1

摘要

谷丙转氨酶(ALT)和天冬氨酸转氨酶(AST)是参与氨基酸代谢的细胞内酶。对它们活动的测量是临床实验室中最常用的两种测试,用于筛查、诊断和跟踪影响肝脏的疾病。最近的研究强调,ALT和AST的参考值与许多其他生物标志物一样,根据分析方法和个体特征而变化。ALT的参考值在不同的分析方法(添加磷酸吡哆醛时更高)、性别(男性高于女性)、体重指数(正相关)和年龄(婴儿和老年人更高)之间存在显著差异,但在种族或使用的分析仪之间没有差异。根据分析方法和年龄,报告的AST参考值与ALT类似,具有临床显著性差异。这些观察结果证明,临床实验室有兴趣根据性别、体重指数、年龄(特别是在向儿童或老年人人群提供检测时)和所采用的分析方法更新参考值。如果可能,应使用标准化方法,包括补充磷酸吡哆醛样品,以确保实验室之间结果的可比性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Usual transaminase values: should they be reviewed and adjusted?

Alanine (ALT) and aspartate aminotransferases (AST) are intracellular enzymes involved in the metabolism of amino acids. The measurements of their activities are two of the most ordered tests in clinical laboratories, used to screen, diagnose and follow diseases affecting the liver. Recent works highlighted that reference values for ALT and AST vary according to the analytical method and the individual’s characteristics, like with many other biomarkers. Reference values for ALT show clinically significant differences according to the analytical method (higher when supplementing samples with phosphate pyridoxal), gender (higher in males than in females), body mass index (positive correlation), and age (higher in infants and the elderly), but not according to ethnicity or employed analyzer. According to the analytical method and age, reported reference values for AST show clinically significant differences, similar to ALT. These observations prove clinical laboratories’ interest in updating their reference values according to sex, body mass index, age (especially when providing testing to pediatric or elderly populations), and the analytical method employed. If possible, a standardized method should be used, including sample supplementation with pyridoxal phosphate, to ensure the comparability of results between laboratories.

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来源期刊
Annales de biologie clinique
Annales de biologie clinique 医学-医学:研究与实验
CiteScore
0.80
自引率
20.00%
发文量
53
审稿时长
6-12 weeks
期刊介绍: Multidisciplinary information with direct relevance to everyday practice Annales de Biologie Clinique, the official journal of the French Society of Clinical Biology (SFBC), supports biologists in areas including continuing education, laboratory accreditation and technique validation. With original articles, abstracts and accounts of everyday practice, the journal provides details of advances in knowledge, techniques and equipment, as well as a forum for discussion open to the entire community.
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