老年人声带皱褶中的成纤维细胞浓度

IF 2.5 4区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Journal of Voice Pub Date : 2025-05-01 DOI:10.1016/j.jvoice.2022.10.017

Neemias S. Carneiro , Adriana B.B. Pessin , Sergio A. Rodrigues , Claudia H. Pellizon , Claudia M. Xavier , Regina H.G. Martins

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引用次数: 0

摘要

目的：研究老年人声带中成纤维细胞的浓度：研究老年人声带中成纤维细胞的浓度：摘取 13 具尸体的声带，将其分为两个年龄组，对照组：n-5，18-40 岁；老年组：n-8，≥75 岁：对照组：n-5，18-40 岁；老年组：n-8，≥75 岁）。解剖声带后，使用成纤维细胞 SA100 抗体进行免疫组化分析。分析部位为黄斑和声带内侧（或振动）。使用 AVsoft 程序对细胞进行计数：结果：青壮年喉部黄斑和老年人声带内侧的成纤维细胞浓度较高。然而，这些结果在统计学上没有显著差异，因此我们可以得出结论：年龄对声带中成纤维细胞的浓度没有影响：结论：在老年人的喉部，黄斑部和声带主体中的成纤维细胞数量与年轻人相似，这可能是固有层中纤维基质不断产生的原因。这些细胞的功能变化可能比数量变化更明显。

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Concentration of Fibroblasts in the Vocal Fold of Elderly

Objective

To study the concentration of fibroblasts in the vocal folds of elderly people.

Material and Methods

The vocal folds of 13 cadavers were removed and divided into two age groups: Control group: n-5, 18-40 years; Elderly group: n-8, ≥75 years). The vocal folds were dissected and prepared for immunohistochemical analysis using the SA100 antibody to fibroblasts. The sites analyzed were maculae flavae and medial (or vibrating) portion of the vocal folds. The AVsoft program was used to count the cells.

Results

A higher concentration of fibroblasts was identified in the maculae flavae of the larynx of young adults and in the medial portion of the vocal folds of the elderly. However, these results did not determine statistically significant differences, allowing us to conclude that there was no effect of age on the concentration of fibroblasts in the vocal folds.

Conclusion

In the larynx of the elderly, the fibroblast population remains similar to the young adults, both in the maculae flavae and in the body of the vocal folds, possibly being responsible for the constant production of fibrous matrix in the lamina propria. Functional changes in these cells are probably more marked than quantitative ones.

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来源期刊

Journal of Voice 医学-耳鼻喉科学

CiteScore

4.00

自引率

13.60%

发文量

395

审稿时长

59 days

期刊介绍： The Journal of Voice is widely regarded as the world''s premiere journal for voice medicine and research. This peer-reviewed publication is listed in Index Medicus and is indexed by the Institute for Scientific Information. The journal contains articles written by experts throughout the world on all topics in voice sciences, voice medicine and surgery, and speech-language pathologists'' management of voice-related problems. The journal includes clinical articles, clinical research, and laboratory research. Members of the Foundation receive the journal as a benefit of membership.