具有增强抗菌和骨活性的海胆型二氧化硅稳定氧化锆纳米球的研制。

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
Jiyu Han, Siyu Liu, Songtao Ai, Daqian Wan
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引用次数: 0

摘要

氧化锆基陶瓷在硬组织替代和植入方面的应用带来了新的希望。在三种形式的氧化锆(ZrO2)中,四角形(t-ZrO2)与其他两种形式相比具有较高的机械稳定性,使其适合制造具有增强骨活性的生物医学植入物。本文采用溶胶-凝胶法制备了由硅稳定氧化锆(1:1)组成的四方相纳米球。FESEM分析显示,纳米球呈海胆型形态。XRD谱图证实了在650℃高温煅烧后形成的t -SiO2-ZrO2二元相。通过XRD和FTIR分析证实,在SBF中浸泡研究有助于在托盘上逐渐形成一层磷灰石,时间为7、14、21和28天。此外,通过MTT法对t- SiO2 - ZrO2样品进行MG-63细胞株细胞毒性试验。采用菌落形成单元法对革兰氏阳性菌和革兰氏阴性菌的抑菌性能进行了定量研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development of sea urchin type silica stabilised zirconia nanospheres with enhanced antimicrobial and osteoactivity properties.

Zirconia based ceramics are giving new hope in hard tissues replacement and implants application. Among the three forms of zirconia (ZrO2), tetragonal form (t-ZrO2) possess high mechanical stability in comparison with the other two which makes it suitable for fabricating biomedical implants with enhanced osteo activity. Here, tetragonal phase nanospheres consisting of silica stabilised zirconia (1:1) were prepared via sol gel method. The nanospheres exhibit sea urchin type morphology as observed from FESEM analysis. XRD patterns confirm the formation of t -SiO2-ZrO2 binary phase after high temperature calcination at 650°C. The immersion studies in SBF help in the formation of a layer of apatite in a gradual manner over the pallets for the period of 7, 14, 21 and 28 days which was confirmed by XRD, FTIR analysis. Moreover, t- SiO2 - ZrO2 samples were subjected to cytotoxicity tests through MTT assay on MG-63 cell lines. Antibacterial properties were investigated quantitatively using colony forming unit method against both gram positive as well as gram-negative bacteria.

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来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
期刊介绍: ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/​Abstracted: Web of Science SCIE Scopus CAS INSPEC Portico
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