高压氧治疗诱导大鼠脊髓损伤模型的分子和通路改变:蛋白质组学分析。

IF 2.3 4区医学 Q3 PHARMACOLOGY & PHARMACY

Dose-Response Pub Date : 2022-11-24 eCollection Date: 2022-10-01 DOI:10.1177/15593258221141579

Zhuo Li, Xiaomin Hou, Xuehua Liu, Linlin Ma, Jiewen Tan

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引用次数: 1

摘要

高压氧治疗(HBOT)对脊髓损伤(SCI)有明确的治疗作用，但其作用机制尚不清楚。在这里，我们进行了系统蛋白质组学分析，以鉴定SCI大鼠和HBOT + SCI大鼠之间的差异表达蛋白(DEPs)。功能聚类分析显示，DEPs富集最多的途径包括氧转运活性、氧结合和调节T细胞增殖。功能和信号通路分析结果显示，SCI + HBOT组的代谢途径、生热作用、LXR/RXR激活、急性期反应信号通路、内在凝血酶原途径均高于SCI组。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Hyperbaric Oxygen Therapy-Induced Molecular and Pathway Changes in a Rat Model of Spinal Cord Injury: A Proteomic Analysis.

查看原文本刊更多论文

Hyperbaric Oxygen Therapy-Induced Molecular and Pathway Changes in a Rat Model of Spinal Cord Injury: A Proteomic Analysis.

Hyperbaric Oxygen Therapy (HBOT) has definitive therapeutic effects on spinal cord injury (SCI), but its mechanism of action is still unclear. Here, we've conducted a systemic proteomic analysis to identify differentially expressed proteins (DEPs) between SCI rats and HBOT + SCI rats. The function clustering analysis showed that the top enriched pathways of DEPs include oxygen transport activity, oxygen binding, and regulation of T cell proliferation. The results of functional and signal pathway analyses indicated that metabolic pathways, thermogenesis, LXR/RXR activation, acute phase response signaling, and the intrinsic prothrombin pathway in the SCI + HBOT group was higher than SCI group.

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来源期刊

Dose-Response PHARMACOLOGY & PHARMACY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

CiteScore

4.90

自引率

4.00%

发文量

140

审稿时长

>12 weeks

期刊介绍： Dose-Response is an open access peer-reviewed online journal publishing original findings and commentaries on the occurrence of dose-response relationships across a broad range of disciplines. Particular interest focuses on experimental evidence providing mechanistic understanding of nonlinear dose-response relationships.