高压氧治疗诱导大鼠脊髓损伤模型的分子和通路改变:蛋白质组学分析。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2022-11-24 eCollection Date: 2022-10-01 DOI:10.1177/15593258221141579

Zhuo Li, Xiaomin Hou, Xuehua Liu, Linlin Ma, Jiewen Tan

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引用次数: 1

摘要

高压氧治疗(HBOT)对脊髓损伤(SCI)有明确的治疗作用，但其作用机制尚不清楚。在这里，我们进行了系统蛋白质组学分析，以鉴定SCI大鼠和HBOT + SCI大鼠之间的差异表达蛋白(DEPs)。功能聚类分析显示，DEPs富集最多的途径包括氧转运活性、氧结合和调节T细胞增殖。功能和信号通路分析结果显示，SCI + HBOT组的代谢途径、生热作用、LXR/RXR激活、急性期反应信号通路、内在凝血酶原途径均高于SCI组。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Hyperbaric Oxygen Therapy-Induced Molecular and Pathway Changes in a Rat Model of Spinal Cord Injury: A Proteomic Analysis.

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Hyperbaric Oxygen Therapy-Induced Molecular and Pathway Changes in a Rat Model of Spinal Cord Injury: A Proteomic Analysis.

Hyperbaric Oxygen Therapy (HBOT) has definitive therapeutic effects on spinal cord injury (SCI), but its mechanism of action is still unclear. Here, we've conducted a systemic proteomic analysis to identify differentially expressed proteins (DEPs) between SCI rats and HBOT + SCI rats. The function clustering analysis showed that the top enriched pathways of DEPs include oxygen transport activity, oxygen binding, and regulation of T cell proliferation. The results of functional and signal pathway analyses indicated that metabolic pathways, thermogenesis, LXR/RXR activation, acute phase response signaling, and the intrinsic prothrombin pathway in the SCI + HBOT group was higher than SCI group.

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.