腹腔注射水杨酸/Fe3O4纳米颗粒对C57BL/6小鼠肝脏组织病理学的影响

Current Health Sciences Journal Pub Date : 2022-04-01 Epub Date: 2022-06-30 DOI:10.12865/CHSJ.48.02.02
Bogdan Mîndrilă, Ion Rogoveanu, Sandra-Alice Buteică, Liliana Cercelaru, Dan-Eduard Mihaiescu, Marina-Daniela Mănescu, Ion Mîndrilă, Ionica Pirici
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引用次数: 0

摘要

氧化铁纳米颗粒具有简单的合成和易于工程化的物理化学性质,已广泛应用于多种生物医学领域。IONPs毒性的研究已经成为一个重要的问题,特别是目前报道的结果是相互矛盾的,范围从缺乏毒性到细胞毒性。本研究的目的是评价长期腹腔注射低剂量水杨酸功能化IONPs (SaIONPs)对小鼠肝脏的组织病理学改变。C57BL/6小鼠腹腔注射SaIONPs水悬液(含20mg/kg体重Fe3O4的SaIONPs为35mg/kg体重),每2天注射0.6ml,持续28天。本研究结果表明,累积剂量105mg/kg体重的SaIONPs (62mg/kg体重的Fe3O4)诱导小鼠肝脏包膜下区域的组织病理改变,可能是水杨酸释放到腹腔。244mg/kg体重SaIONPs (145mg/kg体重Fe3O4)的累积剂量诱导肝脏小叶中心坏死,这需要在生物应用中使用更低的剂量。然而,这可能在SaIONPs有针对性积累的情况下是有益的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Liver Histopathological Changes Related to Intraperitoneal Administration of Salicylic Acid/Fe3O4 Nanoparticles to C57BL/6 Mice.

Liver Histopathological Changes Related to Intraperitoneal Administration of Salicylic Acid/Fe3O4 Nanoparticles to C57BL/6 Mice.

Liver Histopathological Changes Related to Intraperitoneal Administration of Salicylic Acid/Fe3O4 Nanoparticles to C57BL/6 Mice.

Liver Histopathological Changes Related to Intraperitoneal Administration of Salicylic Acid/Fe3O4 Nanoparticles to C57BL/6 Mice.

With a simple synthesis and easy engineering of physicochemical properties, iron oxide nanoparticles (IONPs) have become widely used in multiple biomedical applications. The study of IONPs toxicity has become an important issue, especially as the results reported so far are contradictory and range from lack of toxicity to cellular toxicity. The aim of this study was to evaluate the histopathological changes induced in mouse liver by long-term intraperitoneal injection of low doses of IONPs functionalized with salicylic acid (SaIONPs). The study was performed on C57BL/6 mice that received by intraperitoneal injection (IP), every two days, 0.6ml of SaIONPs aqueous suspension (35mg/kg body weight SaIONPs that contained 20mg/kg body weight of Fe3O4) for 28 days. The results of this study showed that the cumulative dose of 105mg/kg body weight SaIONPs (62mg/kg body weight of Fe3O4) induced histopathological changes in the subcapsular region of the mouse liver, possible by the release of salicylic acid into the peritoneal cavity. The cumulative dose of 244mg/kg body weight SaIONPs (145mg/kg body weight of Fe3O4) induced liver centrilobular necrosis, which requires the use of lower doses in biological applications. However, this may prove to be beneficial in the case of targeted accumulation of SaIONPs.

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