{"title":"n -氧化法测定制剂中盐酸甲氧氯普胺的含量。","authors":"Mykola Blazheyevskiy, Deghinmotei Alfred-Ugbenbo, Olena Oleksandrivna Mozgova, Valery Petrovich Moroz","doi":"10.4274/tjps.galenos.2021.33733","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To develop two (titrimetric and spectrophotometric) simple, rapid, sensitive and cost-effective methods for the determination of metoclopramide (MCP) in pharmaceutical dosage forms.</p><p><strong>Materials and methods: </strong>The titrimetric method (A) was based on the <i>N</i>-oxidation reaction involving the use of potassium hydrogen peroxymonosulfate and subsequent iodometric back titration of a known residual reagent. The spectrophotometric method (B) was based on derivatization of MCP with potassium hydrogen peroxymonosulfate in the presence of iodide to produce a chromogen (triiodide) with a wavelength of maximum absorption at 350 nm.</p><p><strong>Results: </strong>Method \"A\" was applicable over the concentration range of 0.25-3.5 mg to end volume 10 mL. In method \"B\", Beer's law was obeyed over the concentration range of 0.3-3.5 μg/mL with molar absorptivity of 24600 L/mol cm. The limits of quantification were calculated to be 0.25 mg/10 mL (A) and 0.2 μg/mL (B), respectively.</p><p><strong>Conclusion: </strong>The proposed methods were suitable for determination of MCP as a pure substance in tablets and injection.</p>","PeriodicalId":23378,"journal":{"name":"Turkish Journal of Pharmaceutical Sciences","volume":"19 5","pages":"589-594"},"PeriodicalIF":1.8000,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634443/pdf/TJPS-19-589.pdf","citationCount":"0","resultStr":"{\"title\":\"Determination of Metoclopramide Hydrochloride in Pharmaceutical Formulations using <i>N</i>-Oxidation Caroate.\",\"authors\":\"Mykola Blazheyevskiy, Deghinmotei Alfred-Ugbenbo, Olena Oleksandrivna Mozgova, Valery Petrovich Moroz\",\"doi\":\"10.4274/tjps.galenos.2021.33733\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>To develop two (titrimetric and spectrophotometric) simple, rapid, sensitive and cost-effective methods for the determination of metoclopramide (MCP) in pharmaceutical dosage forms.</p><p><strong>Materials and methods: </strong>The titrimetric method (A) was based on the <i>N</i>-oxidation reaction involving the use of potassium hydrogen peroxymonosulfate and subsequent iodometric back titration of a known residual reagent. The spectrophotometric method (B) was based on derivatization of MCP with potassium hydrogen peroxymonosulfate in the presence of iodide to produce a chromogen (triiodide) with a wavelength of maximum absorption at 350 nm.</p><p><strong>Results: </strong>Method \\\"A\\\" was applicable over the concentration range of 0.25-3.5 mg to end volume 10 mL. In method \\\"B\\\", Beer's law was obeyed over the concentration range of 0.3-3.5 μg/mL with molar absorptivity of 24600 L/mol cm. The limits of quantification were calculated to be 0.25 mg/10 mL (A) and 0.2 μg/mL (B), respectively.</p><p><strong>Conclusion: </strong>The proposed methods were suitable for determination of MCP as a pure substance in tablets and injection.</p>\",\"PeriodicalId\":23378,\"journal\":{\"name\":\"Turkish Journal of Pharmaceutical Sciences\",\"volume\":\"19 5\",\"pages\":\"589-594\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2022-10-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634443/pdf/TJPS-19-589.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Turkish Journal of Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4274/tjps.galenos.2021.33733\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Turkish Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4274/tjps.galenos.2021.33733","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Determination of Metoclopramide Hydrochloride in Pharmaceutical Formulations using N-Oxidation Caroate.
Objectives: To develop two (titrimetric and spectrophotometric) simple, rapid, sensitive and cost-effective methods for the determination of metoclopramide (MCP) in pharmaceutical dosage forms.
Materials and methods: The titrimetric method (A) was based on the N-oxidation reaction involving the use of potassium hydrogen peroxymonosulfate and subsequent iodometric back titration of a known residual reagent. The spectrophotometric method (B) was based on derivatization of MCP with potassium hydrogen peroxymonosulfate in the presence of iodide to produce a chromogen (triiodide) with a wavelength of maximum absorption at 350 nm.
Results: Method "A" was applicable over the concentration range of 0.25-3.5 mg to end volume 10 mL. In method "B", Beer's law was obeyed over the concentration range of 0.3-3.5 μg/mL with molar absorptivity of 24600 L/mol cm. The limits of quantification were calculated to be 0.25 mg/10 mL (A) and 0.2 μg/mL (B), respectively.
Conclusion: The proposed methods were suitable for determination of MCP as a pure substance in tablets and injection.
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