高胆红素血症病犬的临床发现及存活相关因素评估:澳大利亚维多利亚州 115 例病例(2015-2020 年)。

IF 1.3 Q2 VETERINARY SCIENCES
Veterinary Record Open Pub Date : 2022-08-16 eCollection Date: 2022-12-01 DOI:10.1002/vro2.42
Abigail Brough, Charles Caraguel, Susan Ciaravolo, Alison Stickney
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引用次数: 0

摘要

引言高胆红素血症是犬类医学中一个重要的临床病理学发现。本研究的目的是描述高胆红素血症犬的临床表现和预后,并确定与存活率相关的因素:对南澳大利亚两个转诊中心的高胆红素血症患犬进行回顾性研究(2015-2020 年)。信号、临床症状、临床病理数据、诊断和结果均来自临床记录的检索。采用单变量分析和逻辑回归模型比较结果和总生存率:结果:共纳入 115 例病例。最常见的临床症状是呕吐(63.5%)、厌食(62.6%)、嗜睡(55.7%)和热病(18.3%)。18例(15.7%)确诊为肝前黄疸,51例(44.3%)确诊为肝性黄疸,42例(36.5%)确诊为肝后黄疸。所有病例的中位生存时间为 40 天(95% 置信区间 [CI]:9-126 天)。诊断时血清胆红素大于 60 μmol/L 的犬的死亡风险增加(几率比 [OR] = 3.55;95% 置信区间 [CI]:1.53-8.22;P 值 = 0.003),与肝性(OR = 4.35;95% CI:1.18-16.0;p-value = 0.027)和肝后性(OR = 6.52;95% CI:1.67-25.5;p-value = 0.007)黄疸犬相比,肝前性黄疸犬的肝性(OR = 4.35;95% CI:1.18-16.0;p-value = 0.027):结论:肝前性黄疸的死亡风险明显高于肝性和肝后性黄疸。诊断时血清胆红素大于 60 μmol/L 与中位生存时间明显缩短有关。这一临界值可能有助于与主人讨论进一步的诊断检查和治疗。还需要进一步的前瞻性研究来证明这一临界值的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Clinical findings and assessment of factors associated with survival in dogs presenting with hyperbilirubinaemia: 115 cases in Victoria, Australia (2015-2020).

Clinical findings and assessment of factors associated with survival in dogs presenting with hyperbilirubinaemia: 115 cases in Victoria, Australia (2015-2020).

Clinical findings and assessment of factors associated with survival in dogs presenting with hyperbilirubinaemia: 115 cases in Victoria, Australia (2015-2020).

Clinical findings and assessment of factors associated with survival in dogs presenting with hyperbilirubinaemia: 115 cases in Victoria, Australia (2015-2020).

Introduction: Hyperbilirubinaemia is an important clinicopathological finding in canine medicine. The objectives of this study were to describe the clinical presentation and outcome of dogs with hyperbilirubinaemia; also to identify factors associated with survival.

Materials and methods: Retrospective study of dogs with hyperbilirubinaemia from two referral centres in South Australia (2015-2020). Signalment, clinical signs, clinicopathological data, diagnosis and outcome were obtained from searching clinical records. Univariable analysis and logistic regression modelling were used to compare outcomes and overall survival.

Results: A total of 115 cases were included. The most common clinical signs were vomiting (63.5%), anorexia (62.6%), lethargy (55.7%) and pyrexia (18.3%). Pre-hepatic icterus was diagnosed in 18 cases (15.7%), hepatic icterus in 51 cases (44.3%) and post-hepatic icterus in 42 cases (36.5%). The median survival time across all cases was 40 days (95% confidence interval [CI]: 9-126 days). There was an increased risk of death in dogs with serum bilirubin greater than 60 μmol/L at diagnosis (odds ratio [OR] = 3.55; 95% CI: 1.53-8.22; p-value = 0.003) and in dogs with pre-hepatic icterus compared to hepatic (OR = 4.35; 95% CI: 1.18-16.0; p-value = 0.027) and post-hepatic icterus (OR = 6.52; 95% CI: 1.67-25.5; p-value = 0.007).

Conclusions: Pre-hepatic icterus was associated with a significantly higher risk of death than hepatic and post-hepatic icterus. Serum bilirubin >60 μmol/L at diagnosis was associated with a significantly shorter median survival time. This cut-off may be useful in discussions with owners regarding pursuing further diagnostic investigation and treatment. Further prospective studies are needed to prove the validity of this cut-off.

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来源期刊
Veterinary Record Open
Veterinary Record Open VETERINARY SCIENCES-
CiteScore
3.00
自引率
0.00%
发文量
25
审稿时长
19 weeks
期刊介绍: Veterinary Record Open is a journal dedicated to publishing specialist veterinary research across a range of topic areas including those of a more niche and specialist nature to that considered in the weekly Vet Record. Research from all disciplines of veterinary interest will be considered. It is an Open Access journal of the British Veterinary Association.
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