非季节性抑郁症和晚睡型患者辅助光治疗的随机对照试验中退出的预测。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Joey W Y Chan, Shirley Xin Li, Steven Wai Ho Chau, Ngan Yin Chan, Jihui Zhang, Yun Kwok Wing
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引用次数: 1

摘要

本研究通过比较93例单极非季节性抑郁症和夜间睡眠型患者的临床特征并进行逻辑回归分析,研究了在为期5周的渐进轻度治疗(LT)期间辍学的可能预测因素。93名(20%)受试者中有19名(80%为女性,年龄46.5±11.7岁)在5周的光照治疗期间退出。在控制了潜在的混杂因素(包括年龄、性别、治疗组、基线上升时间、患者期望和治疗中出现的不良事件)后,第一个治疗周的治疗不依从性(即接受LT少于规定持续时间的80%)预示着光治疗期间退出风险增加5倍(OR: 5.85, CI: 1.41-24.21)。有必要在研究和临床环境中纳入加强治疗依从性和保留性的战略。中国临床试验注册中心(ChiCTR-IOR-15006937)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Prediction of Dropout in a Randomized Controlled Trial of Adjunctive Light Treatment in Patients with Non-Seasonal Depression and Evening Chronotype.

Prediction of Dropout in a Randomized Controlled Trial of Adjunctive Light Treatment in Patients with Non-Seasonal Depression and Evening Chronotype.

The current study examined the possible predictors of dropout during a five-week light treatment (LT) with a gradual advance protocol in 93 patients with unipolar non-seasonal depression and evening chronotypes by comparing their clinical characteristics and performing a logistic regression analysis. Nineteen out of ninety-three (20%) subjects (80% female, 46.5 ± 11.7 years old) dropped out during the 5-week light treatment. Treatment non-adherence (i.e., receiving LT for less than 80% of the prescribed duration) over the first treatment week predicted a five-fold increase in risk of dropout during light therapy (OR: 5.85, CI: 1.41-24.21) after controlling for potential confounders, including age, gender, treatment group, rise time at the baseline, patient expectation, and treatment-emergent adverse events. There is a need to incorporate strategies to enhance treatment adherence and retention in both research and clinical settings. Chinese clinical trial registry (ChiCTR-IOR-15006937).

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
期刊介绍: ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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