Harry J Gould, Samantha Edenfield, Paige R Miller, Kelly Jean Sherman, Brian Melius, Alissa Whitney, Robert P Hunter, Fabio Del Piero, Dennis Tracey, Dennis Paul
{"title":"靶向渗透裂解在伴侣动物晚期癌治疗中的作用:一个病例系列。","authors":"Harry J Gould, Samantha Edenfield, Paige R Miller, Kelly Jean Sherman, Brian Melius, Alissa Whitney, Robert P Hunter, Fabio Del Piero, Dennis Tracey, Dennis Paul","doi":"10.1155/2022/2747108","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Targeted osmotic lysis (TOL) is a novel technology that involves concomitant stimulation of voltage-gated sodium channels (VGSCs) and the pharmacological blockade of Na<sup>+</sup>, K<sup>+</sup>-ATPase causing lysis of highly malignant cancer cells. <i>Hypothesis/Objectives</i>. TOL offers an option for treating advanced carcinomas in companion animals. <i>Animals</i>. Two cats and 2 dogs that presented to veterinary hospitals for evaluation and treatment of one of several forms of carcinoma.</p><p><strong>Methods: </strong>Digoxin was administered to achieve steady-state, therapeutic concentrations. The animals were then exposed to pulsed electric field stimulation. Pre- and posttreatment assessments of tumor size and quality of life were compared. The treatment frequency and survivability varied, based on the patient's premorbid functioning and response to treatment.</p><p><strong>Results: </strong>Regardless of cancer type, TOL consistently increased survival beyond expected, often improving, but without compromising of quality of life. <i>Conclusions and Clinical Importance</i>. TOL warrants consideration as an option for managing advanced carcinomas.</p>","PeriodicalId":37339,"journal":{"name":"Case Reports in Veterinary Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363929/pdf/","citationCount":"1","resultStr":"{\"title\":\"The Role of Targeted Osmotic Lysis in the Treatment of Advanced Carcinoma in Companion Animals: A Case Series.\",\"authors\":\"Harry J Gould, Samantha Edenfield, Paige R Miller, Kelly Jean Sherman, Brian Melius, Alissa Whitney, Robert P Hunter, Fabio Del Piero, Dennis Tracey, Dennis Paul\",\"doi\":\"10.1155/2022/2747108\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Targeted osmotic lysis (TOL) is a novel technology that involves concomitant stimulation of voltage-gated sodium channels (VGSCs) and the pharmacological blockade of Na<sup>+</sup>, K<sup>+</sup>-ATPase causing lysis of highly malignant cancer cells. <i>Hypothesis/Objectives</i>. TOL offers an option for treating advanced carcinomas in companion animals. <i>Animals</i>. Two cats and 2 dogs that presented to veterinary hospitals for evaluation and treatment of one of several forms of carcinoma.</p><p><strong>Methods: </strong>Digoxin was administered to achieve steady-state, therapeutic concentrations. The animals were then exposed to pulsed electric field stimulation. Pre- and posttreatment assessments of tumor size and quality of life were compared. The treatment frequency and survivability varied, based on the patient's premorbid functioning and response to treatment.</p><p><strong>Results: </strong>Regardless of cancer type, TOL consistently increased survival beyond expected, often improving, but without compromising of quality of life. <i>Conclusions and Clinical Importance</i>. TOL warrants consideration as an option for managing advanced carcinomas.</p>\",\"PeriodicalId\":37339,\"journal\":{\"name\":\"Case Reports in Veterinary Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-08-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363929/pdf/\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Case Reports in Veterinary Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2022/2747108\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"Veterinary\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Case Reports in Veterinary Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2022/2747108","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"Veterinary","Score":null,"Total":0}
The Role of Targeted Osmotic Lysis in the Treatment of Advanced Carcinoma in Companion Animals: A Case Series.
Background: Targeted osmotic lysis (TOL) is a novel technology that involves concomitant stimulation of voltage-gated sodium channels (VGSCs) and the pharmacological blockade of Na+, K+-ATPase causing lysis of highly malignant cancer cells. Hypothesis/Objectives. TOL offers an option for treating advanced carcinomas in companion animals. Animals. Two cats and 2 dogs that presented to veterinary hospitals for evaluation and treatment of one of several forms of carcinoma.
Methods: Digoxin was administered to achieve steady-state, therapeutic concentrations. The animals were then exposed to pulsed electric field stimulation. Pre- and posttreatment assessments of tumor size and quality of life were compared. The treatment frequency and survivability varied, based on the patient's premorbid functioning and response to treatment.
Results: Regardless of cancer type, TOL consistently increased survival beyond expected, often improving, but without compromising of quality of life. Conclusions and Clinical Importance. TOL warrants consideration as an option for managing advanced carcinomas.
期刊介绍：
Case Reports in Veterinary Medicine is a peer-reviewed, Open Access journal that publishes case reports and case series in all areas of veterinary medicine.
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