Roya Ghasemian, Azadeh Bandegani, Firoozeh Kermani, Leila Faeli, Behrad Roohi, Elham Yousefi-Abdolmaleki, Mohammad T Hedayati, Emmanuel Roilides, Tahereh Shokohi
{"title":"溺水后致死性金囊孢子菌感染1例。","authors":"Roya Ghasemian, Azadeh Bandegani, Firoozeh Kermani, Leila Faeli, Behrad Roohi, Elham Yousefi-Abdolmaleki, Mohammad T Hedayati, Emmanuel Roilides, Tahereh Shokohi","doi":"10.18502/cmm.7.4.8410","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and purpose: </strong><i>Scedosporium</i> spp. is a saprophytic fungus that may cause invasive pulmonary infection due to the aspiration of contaminated water in both immunosuppressed and immunocompetent hosts.</p><p><strong>Case report: </strong>Herein, we report a fatal case of pulmonary infection caused by <i>Scedosporium</i> species associated with a car crash and near-drowning in a sewage canal. <i>Scedosporium aurantiacum</i> isolated from bronchoalveolar lavage was identified by PCR-sequencing of <i>β-tubulin</i> genes. The minimum inhibitory concentration values for amphotericin B, itraconazole, posaconazole, isavuconazole were >16 µg/ml, and >8 µg/ml for anidulafungin, micafungin, and caspofungin. Voriconazole was found to be the most active agent with a MIC of 1 µg/ml.</p><p><strong>Conclusion: </strong>This report, as the first case of pulmonary scedosporiosis after near-drowning in Iran, highlights the importance of high suspicion in near-drowning victims, prompt identification of <i>Scedosporium</i> spp., and early initiation of appropriate antifungal therapy.</p>","PeriodicalId":10863,"journal":{"name":"Current Medical Mycology","volume":" ","pages":"38-42"},"PeriodicalIF":0.0000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175145/pdf/","citationCount":"1","resultStr":"{\"title\":\"Fatal pulmonary <i>Scedosporium aurantiacum</i> infection in a patient after near-drowning: A case report.\",\"authors\":\"Roya Ghasemian, Azadeh Bandegani, Firoozeh Kermani, Leila Faeli, Behrad Roohi, Elham Yousefi-Abdolmaleki, Mohammad T Hedayati, Emmanuel Roilides, Tahereh Shokohi\",\"doi\":\"10.18502/cmm.7.4.8410\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and purpose: </strong><i>Scedosporium</i> spp. is a saprophytic fungus that may cause invasive pulmonary infection due to the aspiration of contaminated water in both immunosuppressed and immunocompetent hosts.</p><p><strong>Case report: </strong>Herein, we report a fatal case of pulmonary infection caused by <i>Scedosporium</i> species associated with a car crash and near-drowning in a sewage canal. <i>Scedosporium aurantiacum</i> isolated from bronchoalveolar lavage was identified by PCR-sequencing of <i>β-tubulin</i> genes. The minimum inhibitory concentration values for amphotericin B, itraconazole, posaconazole, isavuconazole were >16 µg/ml, and >8 µg/ml for anidulafungin, micafungin, and caspofungin. Voriconazole was found to be the most active agent with a MIC of 1 µg/ml.</p><p><strong>Conclusion: </strong>This report, as the first case of pulmonary scedosporiosis after near-drowning in Iran, highlights the importance of high suspicion in near-drowning victims, prompt identification of <i>Scedosporium</i> spp., and early initiation of appropriate antifungal therapy.</p>\",\"PeriodicalId\":10863,\"journal\":{\"name\":\"Current Medical Mycology\",\"volume\":\" \",\"pages\":\"38-42\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175145/pdf/\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Medical Mycology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18502/cmm.7.4.8410\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Medical Mycology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18502/cmm.7.4.8410","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Fatal pulmonary Scedosporium aurantiacum infection in a patient after near-drowning: A case report.
Background and purpose: Scedosporium spp. is a saprophytic fungus that may cause invasive pulmonary infection due to the aspiration of contaminated water in both immunosuppressed and immunocompetent hosts.
Case report: Herein, we report a fatal case of pulmonary infection caused by Scedosporium species associated with a car crash and near-drowning in a sewage canal. Scedosporium aurantiacum isolated from bronchoalveolar lavage was identified by PCR-sequencing of β-tubulin genes. The minimum inhibitory concentration values for amphotericin B, itraconazole, posaconazole, isavuconazole were >16 µg/ml, and >8 µg/ml for anidulafungin, micafungin, and caspofungin. Voriconazole was found to be the most active agent with a MIC of 1 µg/ml.
Conclusion: This report, as the first case of pulmonary scedosporiosis after near-drowning in Iran, highlights the importance of high suspicion in near-drowning victims, prompt identification of Scedosporium spp., and early initiation of appropriate antifungal therapy.
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