{"title":"运动结合饮食干预对肥胖青少年体成分和血清生化指标的影响：系统回顾和荟萃分析","authors":"Liangyu Zhao, Xiaosheng Dong, Yan Gao, Zhihao Jia, Suyue Han, Juntao Zhang, Yubo Gao","doi":"10.1515/jpem-2022-0193","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This systematic review aims to evaluate the effects of exercise combined with diet (ECWD), exercise alone, diet alone, and no intervention on body composition and serum biochemical markers in adolescents with obesity to provide reference for solving the metabolic disorders of adolescents caused by obesity.</p><p><strong>Contents: </strong>Studies published before January 5, 2021 were retrieved from PubMed, Web of Science, Ovid, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang data, VIP database, and SinoMed. Randomized controlled trials with an age between 10 and 20 years, body mass index (BMI) ≥28 kg/m<sup>2</sup> or ≥95th percentiles, no history of endocrine and metabolic diseases, heart disease, hematologic disease, and so on before the trial were included.</p><p><strong>Summary: </strong>Fifteen of the 50,155 studies met the criteria. Meta-analysis showed that ECWD was more effective in reducing BMI (kg/m<sup>2</sup>) (-2.45 kg/m<sup>2</sup>, 95% CI: -3.06; -1.85) and fat thickness of back (-13.77 mm, 95% CI: -15.92; -11.62), abdomen (-11.56 mm, 95% CI: -14.04; -9.09), and upper arm (-14.81 mm, 95% CI: -16.74; -12.89) than other interventions; in reducing body fat (-7.03 kg, 95% CI: -9.77; -4.29) and thigh circumference (-4.05 cm, 95% CI: -5.58; -2.52), ECWD and diet alone were more effective than exercise alone; ECWD and exercise alone were more effective in reducing waist circumference (-6.05 cm, 95% CI: -8.37; -3.72), waist-to-hip ratio (WHR; -0.06, 95% CI: -0.11; -0.01), upper arm circumference (-2.57 cm, 95% CI: -3.70; -1.45), triglycerides (TG; -0.30 mmol/L, 95% CI: -0.45; -0.14), total cholesterol (TC; -0.30 mmol/L, 95% CI: -0.59; -0.01), and low density lipoprotein (LDL; -0.22 mmol/L, 95% CI: -0.40; -0.04) than diet alone. ECWD also had effects on tumor necrosis factor-α (TNF-α), interleukin-6, leptin, and so on.</p><p><strong>Outlook: </strong>ECWD is more effective than exercise alone, diet alone, or no intervention in solving the problems of body shape and metabolic disorder of adolescents with obesity.</p>","PeriodicalId":520684,"journal":{"name":"Journal of pediatric endocrinology & metabolism : JPEM","volume":" ","pages":"1319-1336"},"PeriodicalIF":1.0000,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of exercise combined with diet intervention on body composition and serum biochemical markers in adolescents with obesity: a systematic review and meta-analysis.\",\"authors\":\"Liangyu Zhao, Xiaosheng Dong, Yan Gao, Zhihao Jia, Suyue Han, Juntao Zhang, Yubo Gao\",\"doi\":\"10.1515/jpem-2022-0193\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>This systematic review aims to evaluate the effects of exercise combined with diet (ECWD), exercise alone, diet alone, and no intervention on body composition and serum biochemical markers in adolescents with obesity to provide reference for solving the metabolic disorders of adolescents caused by obesity.</p><p><strong>Contents: </strong>Studies published before January 5, 2021 were retrieved from PubMed, Web of Science, Ovid, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang data, VIP database, and SinoMed. Randomized controlled trials with an age between 10 and 20 years, body mass index (BMI) ≥28 kg/m<sup>2</sup> or ≥95th percentiles, no history of endocrine and metabolic diseases, heart disease, hematologic disease, and so on before the trial were included.</p><p><strong>Summary: </strong>Fifteen of the 50,155 studies met the criteria. Meta-analysis showed that ECWD was more effective in reducing BMI (kg/m<sup>2</sup>) (-2.45 kg/m<sup>2</sup>, 95% CI: -3.06; -1.85) and fat thickness of back (-13.77 mm, 95% CI: -15.92; -11.62), abdomen (-11.56 mm, 95% CI: -14.04; -9.09), and upper arm (-14.81 mm, 95% CI: -16.74; -12.89) than other interventions; in reducing body fat (-7.03 kg, 95% CI: -9.77; -4.29) and thigh circumference (-4.05 cm, 95% CI: -5.58; -2.52), ECWD and diet alone were more effective than exercise alone; ECWD and exercise alone were more effective in reducing waist circumference (-6.05 cm, 95% CI: -8.37; -3.72), waist-to-hip ratio (WHR; -0.06, 95% CI: -0.11; -0.01), upper arm circumference (-2.57 cm, 95% CI: -3.70; -1.45), triglycerides (TG; -0.30 mmol/L, 95% CI: -0.45; -0.14), total cholesterol (TC; -0.30 mmol/L, 95% CI: -0.59; -0.01), and low density lipoprotein (LDL; -0.22 mmol/L, 95% CI: -0.40; -0.04) than diet alone. ECWD also had effects on tumor necrosis factor-α (TNF-α), interleukin-6, leptin, and so on.</p><p><strong>Outlook: </strong>ECWD is more effective than exercise alone, diet alone, or no intervention in solving the problems of body shape and metabolic disorder of adolescents with obesity.</p>\",\"PeriodicalId\":520684,\"journal\":{\"name\":\"Journal of pediatric endocrinology & metabolism : JPEM\",\"volume\":\" \",\"pages\":\"1319-1336\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2022-09-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of pediatric endocrinology & metabolism : JPEM\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1515/jpem-2022-0193\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/11/25 0:00:00\",\"PubModel\":\"Print\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of pediatric endocrinology & metabolism : JPEM","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/jpem-2022-0193","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/11/25 0:00:00","PubModel":"Print","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
背景：本系统综述旨在评价运动与饮食结合（ECWD）、单独运动、单独饮食和不干预对青少年肥胖患者体成分和血清生化指标的影响，为解决青少年肥胖引起的代谢紊乱提供参考。内容：检索PubMed、Web of Science、Ovid、Cochrane Library、中国知网（CNKI）、万方数据、维普数据库、中国医学信息网（SinoMed）等数据库于2021年1月5日前发表的研究。纳入年龄在10 ~ 20岁，体重指数(BMI)≥28 kg/m2或≥95百分位数，试验前无内分泌代谢疾病、心脏病、血液病等病史的随机对照试验。总结：50,155项研究中有15项符合标准。meta分析显示，ECWD在降低BMI （kg/m2）方面更有效(-2.45 kg/m2, 95% CI: -3.06；-1.85)和背部脂肪厚度(-13.77 mm, 95% CI: -15.92；-11.62)，腹部(-11.56 mm, 95% CI: -14.04；-9.09)，上臂(-14.81 mm, 95% CI: -16.74；-12.89)优于其他干预措施；减少体脂(-7.03 kg, 95% CI: -9.77；-4.29)和大腿围(-4.05 cm, 95% CI: -5.58；-2.52)， ECWD +饮食比单纯运动更有效；ECWD和单独运动在减小腰围方面更有效(-6.05 cm, 95% CI: -8.37；-3.72)，腰臀比(WHR；-0.06, 95% ci: -0.11；-0.01)，上臂围(-2.57 cm, 95% CI: -3.70；-1.45)，甘油三酯(TG；-0.30 mmol/L, 95% CI: -0.45；-0.14)，总胆固醇(TC；-0.30 mmol/L, 95% CI: -0.59；-0.01)，低密度脂蛋白(LDL；-0.22 mmol/L, 95% CI: -0.40；-0.04)比单独饮食要好。ECWD对肿瘤坏死因子-α (TNF-α)、白细胞介素-6、瘦素等也有影响。展望：ECWD比单独运动、单独饮食或不干预更有效地解决青少年肥胖的体型和代谢紊乱问题。
Effects of exercise combined with diet intervention on body composition and serum biochemical markers in adolescents with obesity: a systematic review and meta-analysis.
Background: This systematic review aims to evaluate the effects of exercise combined with diet (ECWD), exercise alone, diet alone, and no intervention on body composition and serum biochemical markers in adolescents with obesity to provide reference for solving the metabolic disorders of adolescents caused by obesity.
Contents: Studies published before January 5, 2021 were retrieved from PubMed, Web of Science, Ovid, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang data, VIP database, and SinoMed. Randomized controlled trials with an age between 10 and 20 years, body mass index (BMI) ≥28 kg/m2 or ≥95th percentiles, no history of endocrine and metabolic diseases, heart disease, hematologic disease, and so on before the trial were included.
Summary: Fifteen of the 50,155 studies met the criteria. Meta-analysis showed that ECWD was more effective in reducing BMI (kg/m2) (-2.45 kg/m2, 95% CI: -3.06; -1.85) and fat thickness of back (-13.77 mm, 95% CI: -15.92; -11.62), abdomen (-11.56 mm, 95% CI: -14.04; -9.09), and upper arm (-14.81 mm, 95% CI: -16.74; -12.89) than other interventions; in reducing body fat (-7.03 kg, 95% CI: -9.77; -4.29) and thigh circumference (-4.05 cm, 95% CI: -5.58; -2.52), ECWD and diet alone were more effective than exercise alone; ECWD and exercise alone were more effective in reducing waist circumference (-6.05 cm, 95% CI: -8.37; -3.72), waist-to-hip ratio (WHR; -0.06, 95% CI: -0.11; -0.01), upper arm circumference (-2.57 cm, 95% CI: -3.70; -1.45), triglycerides (TG; -0.30 mmol/L, 95% CI: -0.45; -0.14), total cholesterol (TC; -0.30 mmol/L, 95% CI: -0.59; -0.01), and low density lipoprotein (LDL; -0.22 mmol/L, 95% CI: -0.40; -0.04) than diet alone. ECWD also had effects on tumor necrosis factor-α (TNF-α), interleukin-6, leptin, and so on.
Outlook: ECWD is more effective than exercise alone, diet alone, or no intervention in solving the problems of body shape and metabolic disorder of adolescents with obesity.
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