Josh McGovern, Ross D Dolan, Donogh Maguire, Paul G Horgan, Barry J Laird, Donald C McMillan
{"title":"来自英国单一中心的非癌症和癌症患者的ct身体成分测量的比较。","authors":"Josh McGovern, Ross D Dolan, Donogh Maguire, Paul G Horgan, Barry J Laird, Donald C McMillan","doi":"10.22540/JFSF-07-117","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Establish the prevalence of low skeletal muscle index and density in our population, by comparing age and sex matched cohorts of patients with and without cancer, using standardized methodology for CT-Body composition (CT-BC).</p><p><strong>Methods: </strong>A retrospective analysis of prospectively collected data. Patients admitted to our institution between 17<sup>th</sup> March 2020 - 1<sup>st</sup> May 2020, with confirmed coronavirus disease and imaging suitable for CT-BC (n=52), were age and sex matched with patients undergoing resection for colorectal cancer (n=52).</p><p><strong>Results: </strong>104 patients were included in the final analysis. 43% (n=45) were male, 77% (n=80) were aged 65 years or older, 50% (n=50) were overweight (BMI ≥25) and 53% (n=55) were systemically inflamed (mGPS ≥1). The prevalence of a low SMI (56% vs. 65%) and low SMD (83% vs. 67%) was similar between cohorts. A low SMI and SMD were both associated with age (p<0.05 and p<0.01, respectively) on univariate analysis. On multivariate analysis, a low SMD was independently associated with age (OR 2.38 (1.34-4.22), p=0.003) and mGPS (OR 2.10 (1.20-3.68), p=0.01).</p><p><strong>Conclusions: </strong>In conclusion, the prevalence of a low SMI and low SMD was similar in non-cancer and cancer cohorts in our institution.</p>","PeriodicalId":73754,"journal":{"name":"Journal of frailty, sarcopenia and falls","volume":" ","pages":"117-122"},"PeriodicalIF":0.0000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e0/30/JFSF-7-117.PMC9433946.pdf","citationCount":"0","resultStr":"{\"title\":\"A comparison of CT-body composition measurements in non-cancer and cancer patients from a single UK centre.\",\"authors\":\"Josh McGovern, Ross D Dolan, Donogh Maguire, Paul G Horgan, Barry J Laird, Donald C McMillan\",\"doi\":\"10.22540/JFSF-07-117\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Establish the prevalence of low skeletal muscle index and density in our population, by comparing age and sex matched cohorts of patients with and without cancer, using standardized methodology for CT-Body composition (CT-BC).</p><p><strong>Methods: </strong>A retrospective analysis of prospectively collected data. Patients admitted to our institution between 17<sup>th</sup> March 2020 - 1<sup>st</sup> May 2020, with confirmed coronavirus disease and imaging suitable for CT-BC (n=52), were age and sex matched with patients undergoing resection for colorectal cancer (n=52).</p><p><strong>Results: </strong>104 patients were included in the final analysis. 43% (n=45) were male, 77% (n=80) were aged 65 years or older, 50% (n=50) were overweight (BMI ≥25) and 53% (n=55) were systemically inflamed (mGPS ≥1). The prevalence of a low SMI (56% vs. 65%) and low SMD (83% vs. 67%) was similar between cohorts. A low SMI and SMD were both associated with age (p<0.05 and p<0.01, respectively) on univariate analysis. On multivariate analysis, a low SMD was independently associated with age (OR 2.38 (1.34-4.22), p=0.003) and mGPS (OR 2.10 (1.20-3.68), p=0.01).</p><p><strong>Conclusions: </strong>In conclusion, the prevalence of a low SMI and low SMD was similar in non-cancer and cancer cohorts in our institution.</p>\",\"PeriodicalId\":73754,\"journal\":{\"name\":\"Journal of frailty, sarcopenia and falls\",\"volume\":\" \",\"pages\":\"117-122\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e0/30/JFSF-7-117.PMC9433946.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of frailty, sarcopenia and falls\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22540/JFSF-07-117\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of frailty, sarcopenia and falls","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22540/JFSF-07-117","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A comparison of CT-body composition measurements in non-cancer and cancer patients from a single UK centre.
Objectives: Establish the prevalence of low skeletal muscle index and density in our population, by comparing age and sex matched cohorts of patients with and without cancer, using standardized methodology for CT-Body composition (CT-BC).
Methods: A retrospective analysis of prospectively collected data. Patients admitted to our institution between 17th March 2020 - 1st May 2020, with confirmed coronavirus disease and imaging suitable for CT-BC (n=52), were age and sex matched with patients undergoing resection for colorectal cancer (n=52).
Results: 104 patients were included in the final analysis. 43% (n=45) were male, 77% (n=80) were aged 65 years or older, 50% (n=50) were overweight (BMI ≥25) and 53% (n=55) were systemically inflamed (mGPS ≥1). The prevalence of a low SMI (56% vs. 65%) and low SMD (83% vs. 67%) was similar between cohorts. A low SMI and SMD were both associated with age (p<0.05 and p<0.01, respectively) on univariate analysis. On multivariate analysis, a low SMD was independently associated with age (OR 2.38 (1.34-4.22), p=0.003) and mGPS (OR 2.10 (1.20-3.68), p=0.01).
Conclusions: In conclusion, the prevalence of a low SMI and low SMD was similar in non-cancer and cancer cohorts in our institution.
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