髓母细胞瘤和朝粒细胞性星形细胞瘤小儿存活者的家长对执行功能的评分。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2024-01-01 Epub Date: 2022-09-16 DOI:10.1080/21622965.2022.2123707
Alice Ann Holland, Jabeen F Shamji, Matthew A Clem, Roger Perez, Jayme M Palka, Peter L Stavinoha
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引用次数: 2

摘要

本研究比较了小儿髓母细胞瘤(MB)和柔毛细胞性星形细胞瘤(PA)幸存者的家长评分执行功能。虽然两者的标准治疗方法都包括手术切除,但髓母细胞瘤患儿还需要接受化疗和颅骨照射。鉴于化疗和颅脑照射对神经认知的后期影响已得到充分证实,我们预计MB幸存者的家长报告的执行功能较差。36名MB幸存者和20名PA幸存者的家长/监护人完成了执行功能行为评定量表(BRIEF)。PA 幸存者确诊时年龄较小(t[51.97] = 3.07,p < .001,d = 0.86),智商较高(t[54] = -3.51,p < .001,d = 0.95)。然而,与甲基溴组相比,除移位量表外, PA 组在所有 BRIEF 量表中都被评为问题明显较多(所有 p 均小于 0.05;d = 0.30 - 1.10)。此外,甲基溴幸存者的所有 BRIEF 平均得分都在正常范围内,而 PA 幸存者的所有 BRIEF 平均得分(材料组织除外)都与正常平均值有明显差异。总体而言,与甲基溴幸存者相比, PA 幸存者的执行功能较差。本文讨论了五种理论来解释这些令人惊讶的结果:两种理论与群体差异有关,两种理论与父母偏见的潜在来源有关,一种理论与基于问卷的评估的性质有关。所有这些理论都是未来研究的方向。像 BRIEF 这样的家长问卷可能对小儿脑肿瘤幸存者有现实意义。未来的研究应探讨影响这些人群家长对执行功能评分的因素,并与基于表现的测量方法进行比较。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Parent ratings of executive functioning in pediatric survivors of medulloblastoma and pilocytic astrocytoma.

The present study compared parent-rated executive functioning in pediatric medulloblastoma (MB) and pilocytic astrocytoma (PA) survivors. Although standard care for both includes surgical resection, children with MB additionally receive chemotherapy and craniospinal irradiation. Given well-documented neurocognitive late effects associated with the latter, we anticipated poor parent-reported executive functioning in MB survivors. Parents/guardians of 36 MB survivors and 20 PA survivors completed the Behavior Rating Inventory of Executive Functioning (BRIEF). PA survivors were younger at diagnosis (t[51.97] = 3.07, p < .001, d = 0.86) and demonstrated higher IQ (t[54] = -3.51, p < .001, d = 0.95). However, relative to the MB group, the PA group was rated as having significantly more problems on all BRIEF scales (all p ≤ .05; d = 0.30 - 1.10), except the Shift scale. Additionally, all mean BRIEF scores for MB survivors were within normal limits, whereas for PA survivors, all mean BRIEF scores except for Organization of Materials were significantly discrepant from normative means. Overall, PA survivors were rated as demonstrating poorer executive function than MB survivors. Five theories are discussed as possible explanations for these surprising findings: two related to group differences, two related to potential sources of parental bias, and one related to the nature of questionnaire-based assessment. All these theories represent directions for future research. Parent questionnaires such as the BRIEF may have real-world implications for pediatric brain tumor survivors. Future research should explore factors affecting parent ratings of executive functioning in these populations, along with comparison to performance-based measures.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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