23例舌全切和近全切喉保留瓣重建治疗效果比较。

IF 0.7 Q4 OTORHINOLARYNGOLOGY
Turkish Archives of Otorhinolaryngology Pub Date : 2022-06-01 Epub Date: 2022-08-31 DOI:10.4274/tao.2022.2022-4-1
Uygar Levent Demir, Mustafa Aslıer, Hakkı Caner İnan
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引用次数: 1

摘要

目的:本研究的目的是评估全舌切除术合并喉保留(TGLP)与近全舌切除术合并喉保留(nTGLP)的功能和肿瘤预后。方法:回顾性分析2010年1月至2020年12月在某三级大学医院接受TGLP或nTGLP治疗的23例患者的资料。评估随访期间的人口学资料、肿瘤分期、手术范围和技术、重建方法、并发症、总生存期(OS)和无复发生存期(RFS)、气管造口术和胃管依赖性。结果:23例符合条件的患者中,接受nTGLP治疗的患者15例(1组),接受TGLP治疗的患者8例(2组)。6个月气管造口依赖率和胃管依赖率分别为3/19(15.7%)和12/19(63.1%),两组间差异无统计学意义。研究人群一年的OS和RFS分别为47.6%和27.8%。OS率仅与淋巴结阳性和结外延伸相关(p=0.004),而在患者组内无统计学意义(p=0.734)。结论:TGLP与nTGLP均为晚期舌癌患者可行的治疗方案,在功能和肿瘤结果上无差异。生存率仍然不令人满意,尽管有适当的治疗,复发率仍然很高。正确选择积极性高且愿意长期术后康复的患者是至关重要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Comparison of Treatment Outcomes Between Total and Near Total Glossectomy with Larynx Preservation and Flap Reconstruction: A Single Institution Experience with 23 Patients.

Comparison of Treatment Outcomes Between Total and Near Total Glossectomy with Larynx Preservation and Flap Reconstruction: A Single Institution Experience with 23 Patients.

Comparison of Treatment Outcomes Between Total and Near Total Glossectomy with Larynx Preservation and Flap Reconstruction: A Single Institution Experience with 23 Patients.

Comparison of Treatment Outcomes Between Total and Near Total Glossectomy with Larynx Preservation and Flap Reconstruction: A Single Institution Experience with 23 Patients.

Objective: The purpose of this study was to evaluate the functional and oncological outcomes of total glossectomy with laryngeal preservation (TGLP) compared to near-total glossectomy with laryngeal preservation (nTGLP).

Methods: In this retrospective study, the data of 23 patients who underwent either TGLP or nTGLP between January 2010 and December 2020 in a tertiary university hospital were analyzed. The data including demographic findings, tumor stage, extent of surgery and technique, method of reconstruction, complications, overall survival (OS) and recurrence-free survival (RFS), and tracheostomy and gastric tube dependence during follow-up were assessed.

Results: Of the 23 eligible patients, 15 had undergone nTGLP (Group 1) and 8 had undergone TGLP (Group 2). Tracheostomy dependence and gastric tube dependence rates at the sixth month were 3/19 (15.7%) and 12/19 (63.1%), respectively, with no significant differences between the two groups. OS and RFS at one year were 47.6% and 27.8%, respectively, for the study population. OS rate showed significance with nodal positivity and extranodal extension (p=0.004 for both) only, but not within patient groups (p=0.734).

Conclusion: Both TGLP and nTGLP are feasible treatment options in patients with advanced tongue cancer with no differences in terms of functional and oncological results. Survival rates are still not satisfactory, and recurrences are high despite appropriate treatments. Proper selection of patients who are highly motivated and willing for long-term postoperative rehabilitation is essential.

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