Ceren Alis, Deniz Alis, Lebriz Uslu Besli, Ercan Karaarslan, Kerim Sonmezoglu, Cigdem Ozkara, Seher Naz Yeni
{"title":"灰质异位患者的18F-FDG PET/MRI、脑电图和符号学分析:一项初步研究","authors":"Ceren Alis, Deniz Alis, Lebriz Uslu Besli, Ercan Karaarslan, Kerim Sonmezoglu, Cigdem Ozkara, Seher Naz Yeni","doi":"10.1111/ane.13705","DOIUrl":null,"url":null,"abstract":"<div>\n \n <section>\n \n <h3> Objectives</h3>\n \n <p>To describe <sup>18</sup>F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (<sup>18</sup>F-FDG PET/MRI) along with semiology and electroencephalography (EEG) in patients with gray matter heterotopia (GMH); to evaluate the concordance between <sup>18</sup>F-FDG PET/MRI and clinical epileptogenic zone (EZ).</p>\n </section>\n \n <section>\n \n <h3> Materials & Methods</h3>\n \n <p>GMH (subcortical heterotopia [SCH] and periventricular nodular heterotopia [PNH]) patients with epilepsy who underwent <sup>18</sup>F-FDG PET/MRI were retrospectively enrolled. Two radiologists evaluated brain MRI, while two nuclear medicine specialists assessed the <sup>18</sup>F-FDG PET. The SUVmax values of visually hypometabolic cortical areas were compared to the contralateral cortex using a SUVmax threshold value of 10%; the SUVmax values of GMH lesions were compared with that of the right precentral gyrus. The cortex or GMH with hypometabolism on <sup>18</sup>F-FDG PET/MRI was considered representative of the EZ. The clinical EZ was identified using EEG and semiology.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Thirty patients (19 PNH; 11 SCH) with a mean age of 28.46 ± 9.52 years were enrolled. The heterotopic nodules were ametabolic in 3 patients (10%), hypometabolic in 16 (33.33%), isometabolic in 13 (26.66%), and hypermetabolic in 4 (10%). <sup>18</sup>F-FDG PET/MRI demonstrated hypometabolism in the cortex and GMH in 22/30 (73.33%) and 16/30 (53.33%). We could identify a clinical EZ in 18 patients, and 15 out of 18 (83.33%) had concordant <sup>18</sup>F-FDG PET/MRI findings.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Heterotopic nodules in GMH patients show different metabolic patterns on <sup>18</sup>F-FDG PET/MRI, with nearly three-quarters of the patients having cortical hypometabolism. <sup>18</sup>F-FDG PET/ MRI findings are mostly concordant with the clinical EZ.</p>\n </section>\n </div>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"146 5","pages":"662-670"},"PeriodicalIF":2.9000,"publicationDate":"2022-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The analysis of 18F-FDG PET/MRI, electroencephalography, and semiology in patients with gray matter heterotopia: A pilot study\",\"authors\":\"Ceren Alis, Deniz Alis, Lebriz Uslu Besli, Ercan Karaarslan, Kerim Sonmezoglu, Cigdem Ozkara, Seher Naz Yeni\",\"doi\":\"10.1111/ane.13705\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <section>\\n \\n <h3> Objectives</h3>\\n \\n <p>To describe <sup>18</sup>F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (<sup>18</sup>F-FDG PET/MRI) along with semiology and electroencephalography (EEG) in patients with gray matter heterotopia (GMH); to evaluate the concordance between <sup>18</sup>F-FDG PET/MRI and clinical epileptogenic zone (EZ).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Materials & Methods</h3>\\n \\n <p>GMH (subcortical heterotopia [SCH] and periventricular nodular heterotopia [PNH]) patients with epilepsy who underwent <sup>18</sup>F-FDG PET/MRI were retrospectively enrolled. Two radiologists evaluated brain MRI, while two nuclear medicine specialists assessed the <sup>18</sup>F-FDG PET. The SUVmax values of visually hypometabolic cortical areas were compared to the contralateral cortex using a SUVmax threshold value of 10%; the SUVmax values of GMH lesions were compared with that of the right precentral gyrus. The cortex or GMH with hypometabolism on <sup>18</sup>F-FDG PET/MRI was considered representative of the EZ. The clinical EZ was identified using EEG and semiology.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Thirty patients (19 PNH; 11 SCH) with a mean age of 28.46 ± 9.52 years were enrolled. The heterotopic nodules were ametabolic in 3 patients (10%), hypometabolic in 16 (33.33%), isometabolic in 13 (26.66%), and hypermetabolic in 4 (10%). <sup>18</sup>F-FDG PET/MRI demonstrated hypometabolism in the cortex and GMH in 22/30 (73.33%) and 16/30 (53.33%). 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The analysis of 18F-FDG PET/MRI, electroencephalography, and semiology in patients with gray matter heterotopia: A pilot study
Objectives
To describe 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (18F-FDG PET/MRI) along with semiology and electroencephalography (EEG) in patients with gray matter heterotopia (GMH); to evaluate the concordance between 18F-FDG PET/MRI and clinical epileptogenic zone (EZ).
Materials & Methods
GMH (subcortical heterotopia [SCH] and periventricular nodular heterotopia [PNH]) patients with epilepsy who underwent 18F-FDG PET/MRI were retrospectively enrolled. Two radiologists evaluated brain MRI, while two nuclear medicine specialists assessed the 18F-FDG PET. The SUVmax values of visually hypometabolic cortical areas were compared to the contralateral cortex using a SUVmax threshold value of 10%; the SUVmax values of GMH lesions were compared with that of the right precentral gyrus. The cortex or GMH with hypometabolism on 18F-FDG PET/MRI was considered representative of the EZ. The clinical EZ was identified using EEG and semiology.
Results
Thirty patients (19 PNH; 11 SCH) with a mean age of 28.46 ± 9.52 years were enrolled. The heterotopic nodules were ametabolic in 3 patients (10%), hypometabolic in 16 (33.33%), isometabolic in 13 (26.66%), and hypermetabolic in 4 (10%). 18F-FDG PET/MRI demonstrated hypometabolism in the cortex and GMH in 22/30 (73.33%) and 16/30 (53.33%). We could identify a clinical EZ in 18 patients, and 15 out of 18 (83.33%) had concordant 18F-FDG PET/MRI findings.
Conclusion
Heterotopic nodules in GMH patients show different metabolic patterns on 18F-FDG PET/MRI, with nearly three-quarters of the patients having cortical hypometabolism. 18F-FDG PET/ MRI findings are mostly concordant with the clinical EZ.
期刊介绍：
Acta Neurologica Scandinavica aims to publish manuscripts of a high scientific quality representing original clinical, diagnostic or experimental work in neuroscience. The journal''s scope is to act as an international forum for the dissemination of information advancing the science or practice of this subject area. Papers in English will be welcomed, especially those which bring new knowledge and observations from the application of therapies or techniques in the combating of a broad spectrum of neurological disease and neurodegenerative disorders. Relevant articles on the basic neurosciences will be published where they extend present understanding of such disorders. Priority will be given to review of topical subjects. Papers requiring rapid publication because of their significance and timeliness will be included as ''Clinical commentaries'' not exceeding two printed pages, as will ''Clinical commentaries'' of sufficient general interest. Debate within the speciality is encouraged in the form of ''Letters to the editor''. All submitted manuscripts falling within the overall scope of the journal will be assessed by suitably qualified referees.
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