接种 CovishieldTM 疫苗前后个体的精液特征。

Huidrom Yaiphaba Meitei, Shubhashree Uppangala, Vani Lakshmi, Guruprasad Kalthur, Satish Kumar Adiga
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引用次数: 0

摘要

担心接种疫苗后生育能力受损是人们对疫苗犹豫不决的原因之一。这项回顾性观察研究旨在了解2018年至2021年期间接受精液分析的53名患者接种CovishieldTM(ChAdOx1 nCoV- 19科罗娜病毒疫苗,重组)COVID-19疫苗对射精质量的影响。受试者在接种疫苗前接受生育检查时记录了精液基线图。在第二剂疫苗接种后约 82 天(Q1:37,Q3:124)提供了后续射精。记录了精液量、精子浓度、精子活力和形态异常等精液特征。在 53 名受试者中,33 人(62%)的精液特征高于世界卫生组织的参考值。总体而言,除了精子形态略有下降(p< 0.05)外,精液参数没有明显变化。有 20 名受试者(38%)的基线精液特征低于世界卫生组织的参考值范围,但在他们的随访样本中并未发现射精质量有明显下降。此外,在随访评估期间,两组研究对象的射精均未出现无精症。我们的研究结果证实,CovishieldTM 疫苗不会损害男性生育能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Semen characteristics of individuals before and after CovishieldTM vaccination.

Concern about fertility impairment after vaccination is one of the reasons for vaccine hesitancy in the population. This retrospective observational study aims to understand the impact of CovishieldTM (ChAdOx1 nCoV- 19 Corona Virus Vaccine, Recombinant) COVID-19 vaccination on ejaculate quality in fifty-three patients undergoing semen analysis between 2018 to 2021. A baseline semen profile was recorded from the subjects during their visit before the vaccination for fertility work-up. Follow-up ejaculates were provided approximately 82 (Q1:37, Q3:124) days after the second dose of vaccination. Semen characteristics such as volume, sperm concentration, sperm motility, and morphological abnormalities were recorded. Of the 53 subjects, 33 (62%) had semen characteristics above the WHO reference. In general, no significant variations in the semen parameters were observed except for a moderate decline in sperm morphology (p< 0.05). The baseline semen characteristics in 20 (38%) subjects were below the WHO reference range; however, no significant decline in the ejaculate quality was observed in their follow-up samples. Further, none of the ejaculates in both study groups were azoospermic during the follow-up evaluation. Our results affirm that CovishieldTM vaccine is not detrimental to male fertility.

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