Hande Erman, Banu Boyuk, Meltem Sertbas, Ali Ozdemir
{"title":"住院患者代谢综合征成分与COVID-19疾病严重程度的关系:一项初步研究","authors":"Hande Erman, Banu Boyuk, Meltem Sertbas, Ali Ozdemir","doi":"10.1155/2022/9682032","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Preliminary data suggest that patients with comorbidities are more susceptible to severe COVID-19 infection. However, data regarding the presence of metabolic syndrome (MetS) in patients with COVID-19 are scarce.</p><p><strong>Aim: </strong>In the present study, we aim to investigate the association between MetS components and disease severity in hospitalized COVID-19 patients.</p><p><strong>Methods: </strong>We conducted a prospective observational study of 90 hospitalized patients with COVID-19 pneumonia at a tertiary hospital. The study population consisted of inpatients who tested positive by the reverse transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2. Patients with critical COVID-19 disease on admission were excluded. Adult Treatment Panel III of the National Cholesterol Education Program (NCEP-ATP III) criteria were used to define MetS. Laboratory analysis and thorax CT were performed on admission.</p><p><strong>Results: </strong>90 patients, 60 moderate and 30 severe COVID-19 patients, included in the study. The percentage of MetS cases was higher among severe COVID-19 patients (<i>p</i>=0.018). Of the MetS criteria fasting blood glucose (<i>p</i>=0.004), triglycerides (<i>p</i>=0.007) were significantly higher in patients with severe COVID-19 disease with no statistical significance found in waist circumference (WC) (<i>p</i>=0.348), systolic blood pressure (<i>p</i>=0.429), and HDL-C levels (<i>p</i>=0.263) between two groups. Body mass index (BMI) values were similar in both severe and moderate cases (<i>p</i>=0.854). In logistic regression analysis, serum triglycerides (<i>p</i>=0.024), HDL-C (<i>p</i>=0.006), and WC (<i>p</i>=0.004) were found as independent prognostic factor for severe COVID-19 infection.</p><p><strong>Conclusion: </strong>Severe COVID-19 patients have higher rates of MetS. Serum triglycerides, HDL-C, and WC have an impact on disease severity in COVID-19.</p>","PeriodicalId":520793,"journal":{"name":"The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale","volume":" ","pages":"9682032"},"PeriodicalIF":2.6000,"publicationDate":"2022-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433267/pdf/","citationCount":"3","resultStr":"{\"title\":\"Relationship between Metabolic Syndrome Components and COVID-19 Disease Severity in Hospitalized Patients: A Pilot Study.\",\"authors\":\"Hande Erman, Banu Boyuk, Meltem Sertbas, Ali Ozdemir\",\"doi\":\"10.1155/2022/9682032\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Preliminary data suggest that patients with comorbidities are more susceptible to severe COVID-19 infection. However, data regarding the presence of metabolic syndrome (MetS) in patients with COVID-19 are scarce.</p><p><strong>Aim: </strong>In the present study, we aim to investigate the association between MetS components and disease severity in hospitalized COVID-19 patients.</p><p><strong>Methods: </strong>We conducted a prospective observational study of 90 hospitalized patients with COVID-19 pneumonia at a tertiary hospital. The study population consisted of inpatients who tested positive by the reverse transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2. Patients with critical COVID-19 disease on admission were excluded. Adult Treatment Panel III of the National Cholesterol Education Program (NCEP-ATP III) criteria were used to define MetS. Laboratory analysis and thorax CT were performed on admission.</p><p><strong>Results: </strong>90 patients, 60 moderate and 30 severe COVID-19 patients, included in the study. The percentage of MetS cases was higher among severe COVID-19 patients (<i>p</i>=0.018). Of the MetS criteria fasting blood glucose (<i>p</i>=0.004), triglycerides (<i>p</i>=0.007) were significantly higher in patients with severe COVID-19 disease with no statistical significance found in waist circumference (WC) (<i>p</i>=0.348), systolic blood pressure (<i>p</i>=0.429), and HDL-C levels (<i>p</i>=0.263) between two groups. Body mass index (BMI) values were similar in both severe and moderate cases (<i>p</i>=0.854). In logistic regression analysis, serum triglycerides (<i>p</i>=0.024), HDL-C (<i>p</i>=0.006), and WC (<i>p</i>=0.004) were found as independent prognostic factor for severe COVID-19 infection.</p><p><strong>Conclusion: </strong>Severe COVID-19 patients have higher rates of MetS. Serum triglycerides, HDL-C, and WC have an impact on disease severity in COVID-19.</p>\",\"PeriodicalId\":520793,\"journal\":{\"name\":\"The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale\",\"volume\":\" \",\"pages\":\"9682032\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2022-08-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433267/pdf/\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1155/2022/9682032\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/2022/9682032","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Relationship between Metabolic Syndrome Components and COVID-19 Disease Severity in Hospitalized Patients: A Pilot Study.
Background: Preliminary data suggest that patients with comorbidities are more susceptible to severe COVID-19 infection. However, data regarding the presence of metabolic syndrome (MetS) in patients with COVID-19 are scarce.
Aim: In the present study, we aim to investigate the association between MetS components and disease severity in hospitalized COVID-19 patients.
Methods: We conducted a prospective observational study of 90 hospitalized patients with COVID-19 pneumonia at a tertiary hospital. The study population consisted of inpatients who tested positive by the reverse transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2. Patients with critical COVID-19 disease on admission were excluded. Adult Treatment Panel III of the National Cholesterol Education Program (NCEP-ATP III) criteria were used to define MetS. Laboratory analysis and thorax CT were performed on admission.
Results: 90 patients, 60 moderate and 30 severe COVID-19 patients, included in the study. The percentage of MetS cases was higher among severe COVID-19 patients (p=0.018). Of the MetS criteria fasting blood glucose (p=0.004), triglycerides (p=0.007) were significantly higher in patients with severe COVID-19 disease with no statistical significance found in waist circumference (WC) (p=0.348), systolic blood pressure (p=0.429), and HDL-C levels (p=0.263) between two groups. Body mass index (BMI) values were similar in both severe and moderate cases (p=0.854). In logistic regression analysis, serum triglycerides (p=0.024), HDL-C (p=0.006), and WC (p=0.004) were found as independent prognostic factor for severe COVID-19 infection.
Conclusion: Severe COVID-19 patients have higher rates of MetS. Serum triglycerides, HDL-C, and WC have an impact on disease severity in COVID-19.
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