人鼠嵌合脑模型的兴起。

IF 4 Q2 CELL & TISSUE ENGINEERING

Cell Regeneration Pub Date : 2022-09-03 DOI:10.1186/s13619-022-00135-6

Peng Jiang, Mahabub Maraj Alam

引用次数: 3

摘要

人-鼠嵌合体为在体内研究人细胞的病理生理提供了有利条件。通过将人类胎儿组织或多能干细胞衍生的祖细胞移植到新生小鼠大脑中，嵌合小鼠大脑已经被创造出来。这为了解人类大脑发育和神经系统疾病提供了新的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Rise of the human-mouse chimeric brain models.

Human-mouse chimeras offer advantages for studying the pathophysiology of human cells in vivo. Chimeric mouse brains have been created by engrafting human fetal tissue- or pluripotent stem cell-derived progenitor cells into the neonatal mouse brain. This provides new opportunities to understand human brain development and neurological disorders.

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来源期刊

Cell Regeneration Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

5.80

自引率

0.00%

发文量

审稿时长

35 days

期刊介绍： Cell Regeneration aims to provide a worldwide platform for researches on stem cells and regenerative biology to develop basic science and to foster its clinical translation in medicine. Cell Regeneration welcomes reports on novel discoveries, theories, methods, technologies, and products in the field of stem cells and regenerative research, the journal is interested, but not limited to the following topics: ◎ Embryonic stem cells ◎ Induced pluripotent stem cells ◎ Tissue-specific stem cells ◎ Tissue or organ regeneration ◎ Methodology ◎ Biomaterials and regeneration ◎ Clinical translation or application in medicine