肿瘤学的因果推理:过去的发展和当前的挑战。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-09-05 eCollection Date: 2023-11-01 DOI:10.1515/ijb-2022-0056

Erica E M Moodie

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引用次数: 2

摘要

在本文中，我们回顾了一些重要的早期发展，在医学统计和流行病学的因果推理是由肿瘤问题的启发。我们研究了文献中的两个经典例子，并指出了当前正在进行的方法学发展领域，即最佳适应性治疗策略的估计。虽然因果分析方法在肿瘤学研究中变得越来越常规，但仍然存在许多令人兴奋的挑战和开放的问题，特别是在审查结果的背景下。

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Causal inference for oncology: past developments and current challenges.

In this paper, we review some important early developments on causal inference in medical statistics and epidemiology that were inspired by questions in oncology. We examine two classical examples from the literature and point to a current area of ongoing methodological development, namely the estimation of optimal adaptive treatment strategies. While causal approaches to analysis have become more routine in oncology research, many exciting challenges and open problems remain, particularly in the context of censored outcomes.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.