Laura Posch-Pertl, Wolfgang List, Monja Michelitsch, Silke Pinter-Hausberger, Florian Posch, Felix Innauer, Wilfried Renner, Martin Weger
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引用次数: 0
摘要
导言最近的一项研究表明,非 O 型血的人患视网膜静脉闭塞(RVO)的风险增加。在这项研究中,我们调查了(i)血型与视网膜静脉阻塞之间的关系,以及(ii)这种关系是否与其他视网膜静脉阻塞风险因素相关:我们在这项病例对照研究中招募了 485 名 RVO 患者和 295 名对照组受试者。我们通过聚合酶链反应测定了作为 O 等位基因标记的 ABO 基因型 rs8176719 和作为 B 等位基因标记的 rs8176746:结果:我们没有发现 ABO 血型与 RVO 存在关联。具体而言,RVO 患者和对照组的 ABO 血型比例相似(p = 0.527)。在逻辑回归中,非 O 型血与 RVO 患者的几率高出 1.06 倍(95% CI:0.78-1.45,p = 0.693),在对年龄、性别、中风和静脉血栓栓塞病史以及联合使用降脂药进行多变量调整后,这种不相关性仍然存在:讨论:虽然非 O 型血是血栓性疾病和心血管疾病的已知风险因素,但它们似乎并不是发生 RVO 的主要风险因素。
Role of the ABO Blood Groups as a Risk Factor for Retinal Vein Occlusion.
Introduction: A recent study suggested that non-O blood groups had an increased risk for the presence of retinal vein occlusion (RVO). In this study, we investigated (i) an association between blood group and the presence of RVO and (ii) whether this association correlated to other RVO risk factors.
Methods: We included 485 RVO patients and 295 control subjects who were recruited in this case-control study. We determined ABO genotypes rs8176719 as a marker for the O allele and rs8176746 for the B allele by polymerase chain reaction.
Results: We did not find an association between ABO blood group and the presence of RVO. In detail, the proportion of ABO blood groups was similar among RVO patients and control subjects (p = 0.527). In a logistic regression, non-O blood group was associated with 1.06-fold higher odds of being a RVO patient (95% CI: 0.78-1.45, p = 0.693), and this lack of association prevailed upon multivariable adjustment for age, gender, history of stroke and venous thromboembolism, and co-medication with lipid-lowering agents.
Discussion: Although non-O blood groups are a known risk factor for thrombotic and cardiovascular disease, they do not seem to be a major risk factor for the development of RVO.
期刊介绍:
''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.