ChAdOx1 nCoV-19疫苗的短期副作用检测:在一个饱受战争蹂躏的国家进行的横断面研究

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2022-08-25 eCollection Date: 2022-01-01 DOI:10.2147/POR.S381836

Mohammed Alshakka, Najmaddin A H Hatem, Wafa Badullah, Rabab Alsakaf, Ali Rageh, Seena Abdulla Yousef, Mohamed Izham Mohamed Ibrahim

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引用次数: 1

摘要

目的:chAdOx1 nCoV-19疫苗是也门首个可用的COVID-19疫苗。因此，这项以当地为基础的研究用于确定首次接种疫苗48小时后短期副作用的类型和频率。方法:通过电话对亚丁接种疫苗的参与者进行横断面调查。采用描述性统计方法进行统计分析。结果:通过方便抽样，共纳入500人。其中27%是卫生保健提供者。近70%的受访者出现了副作用。报告的前三位副作用分别是发热(276例，55.2%)、肌痛(270例，54%)和疲劳(247例，49.4%)。一般来说，大多数参与者表示他们在接种疫苗的第一个24小时后经历了副作用。结论:参与者所经历的副作用与文献没有不同，表明疫苗是安全的。需要进一步研究以确定接种第二剂和第三剂疫苗后的副作用。此外，需要更多的研究来评估现有疫苗对新变种的有效性。

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Detection of Short-Term Side Effects of ChAdOx1 nCoV-19 Vaccine: A Cross-Sectional Study in a War-Torn Country.

Purpose: The chAdOx1 nCoV-19 vaccine is the first COVID-19 vaccine available in Yemen. Hence, this local-based study was used to identify the type and frequency of short-term side effects following 48 hours of the first shot of the vaccine.

Methods: A cross-section of vaccinated participants in Aden were surveyed by telephone. Descriptive statistics were used for statistical analysis.

Results: A total of 500 participants were included through convenient sampling. 27% of them were health care providers. Nearly 70% of the respondent experienced side effects. The top three side effects reported were fever (n=276, 55.2%), myalgia (n=270, 54%) and fatigue (n=247, 49.4%). Generally, most participants stated that they experienced the side effects after the first 24 hours of vaccination.

Conclusion: Side effects that participants experienced were not different from the literature, indicating a safe profile for the vaccine. Further studies are needed to identify the side effects after the second and third dose of the vaccine. In addition, more studies are required to assess the efficacy of the existing vaccines against new variants.

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.