良性前列腺增生患者经尿道前列腺切除术后药物治疗积存症状的危险因素

IF 1.5 4区 医学 Q3 UROLOGY & NEPHROLOGY
Cheng-Han Tsai, Yu-Hua Fan, Alex T. L. Lin, William J. Huang
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引用次数: 0

摘要

目的经尿道前列腺切除术(TURP)后积液症状的持续存在是令人烦恼的,其原因的证据很少。我们试图分析在良性前列腺增生(BPH)患者行TURP后使用抗毒蕈素或β -3激动剂的危险因素。方法回顾性分析行TURP治疗的前列腺增生患者,术后随访6个月。术后储存症状的药物治疗定义为在TURP术后3个月内使用抗毒蕈素或β -3激动剂治疗3个月。评估术前和围手术期变量对术后抗毒蕈素或β -3激动剂处方的影响。结果376例患者中,45例(12.0%)接受了术后药物治疗。双相TURP患者接受术后药物治疗的可能性明显高于单极TURP患者(15.7% vs 6.9%;p = 0.01)。膀胱内前列腺突出1 cm的患者术后使用药物治疗的比例明显高于膀胱内前列腺突出≤1 cm的患者(14.4% vs 5.2%;p = 0.02)。多因素logistic回归分析显示年龄75岁(优势比[OR] 3.04;95% ci 1.29-7.16;P = 0.011),膀胱内前列腺突出1 cm (OR, 3.48;95% ci, 1.32-9.15;P = 0.012),双极经尿道切除(OR 4.25;95% ci 1.53-11.80;P = 0.005)为术后药物治疗的重要危险因素。结论老年、膀胱内前列腺突出和双极TURP与前列腺增生患者TURP术后药物治疗与储存症状显著相关。因此,有这些危险因素的患者可能被告知TURP术后可能需要药物治疗的储存症状的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Risk factors for pharmacotherapy for storage symptoms after transurethral resection of the prostate in patients with benign prostatic hyperplasia

Objectives

Postoperative persistence of storage symptoms after transurethral resection of the prostate (TURP) is bothersome, and evidence of its cause is sparse. We sought to analyze risk factors for using antimuscarinics or beta-3 agonists after TURP in benign prostatic hyperplasia (BPH) patients.

Methods

BPH patients who underwent TURP and were followed up for >6 months after surgery were retrospectively enrolled. Postoperative pharmacotherapy for storage symptoms was defined as the prescription of antimuscarinics or beta-3 agonists within 3 months after TURP for >3 months. Preoperative and perioperative variables were evaluated for their effect on the postoperative prescription of antimuscarinics or beta-3 agonists.

Results

Of the 376 patients, 45 (12.0%) received postoperative pharmacotherapy for storage symptoms. Patients who underwent bipolar TURP were significantly more likely to receive postoperative pharmacotherapy than those who underwent monopolar TURP (15.7% vs 6.9%; P = 0.01). Significantly more patients with intravesical prostatic protrusions >1 cm used postoperative pharmacotherapy than those with protrusions of ≤1 cm (14.4% vs 5.2% respectively; P = 0.02). Multivariate logistic regression analysis revealed age >75 years (odds ratio [OR] 3.04; 95% CI 1.29-7.16; P = 0.011), intravesical prostatic protrusion >1 cm (OR, 3.48; 95% CI, 1.32-9.15; P = 0.012), and bipolar transurethral resection (OR 4.25; 95% CI 1.53-11.80; P = 0.005) as significant risk factors for postoperative pharmacotherapy.

Conclusions

Advanced age, intravesical prostatic protrusion, and bipolar TURP were significantly associated with postoperative pharmacotherapy for storage symptoms after TURP in BPH patients. Therefore, patients with these risk factors might be informed about the risk of postoperative storage symptoms that may require medications after TURP.

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来源期刊
LUTS: Lower Urinary Tract Symptoms
LUTS: Lower Urinary Tract Symptoms UROLOGY & NEPHROLOGY-
CiteScore
3.00
自引率
7.70%
发文量
52
审稿时长
>12 weeks
期刊介绍: LUTS is designed for the timely communication of peer-reviewed studies which provides new clinical and basic science information to physicians and researchers in the field of neurourology, urodynamics and urogynecology. Contributions are reviewed and selected by a group of distinguished referees from around the world, some of whom constitute the journal''s Editorial Board. The journal covers both basic and clinical research on lower urinary tract dysfunctions (LUTD), such as overactive bladder (OAB), detrusor underactivity, benign prostatic hyperplasia (BPH), bladder outlet obstruction (BOO), urinary incontinence, pelvic organ prolapse (POP), painful bladder syndrome (PBS), as well as on other relevant conditions. Case reports are published only if new findings are provided. LUTS is an official journal of the Japanese Continence Society, the Korean Continence Society, and the Taiwanese Continence Society. Submission of papers from all countries are welcome. LUTS has been accepted into Science Citation Index Expanded (SCIE) with a 2011 Impact Factor.
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