因硬膜外血肿而接受手术的早年和中年成年患者的执行功能:一项比较研究。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2024-07-01 Epub Date: 2022-03-20 DOI:10.1080/23279095.2022.2048831
Shweta Singh, Adarsh Tripathi, Bandna Gupta, Seema Rani Sarraf, Girdhar Agarwal, Balkrishna Ojha, P K Dalal
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引用次数: 0

摘要

硬脑膜外血肿(EDH)是一种常见的脑外伤疾病。如果及时进行手术治疗,预后良好。目前还缺乏专门针对 EDH 术后患者执行功能的神经心理学评估研究。此外,年龄作为决定颅脑损伤后患者执行功能的一个变量,其研究对象主要是老年人。这项横断面病例对照研究使用持续注意力、速度、工作记忆、流畅性、集合转换、持久性、计划性和反应抑制等标准化评估工具,对 62 名 EDH 术后患者的执行功能进行了评估,并与 57 名健康对照者(HC)进行了比较。此外,还比较了 EDH 组(E-EDH 和 M-EDH)和 HC 组(E-HC 和 M-HC)在成年早期(20-39 岁)和成年中期(40-60 岁)两个阶段的执行功能。进行了双向方差分析(ANOVA)和相关分析。结果显示,M-EDH 组在执行功能测试(即所需时间、错误和正确反应)中的表现明显较差,其次是 E-EDH、M-HC 和 E-HC。在数字符号、颜色轨迹 1、N-Back 2、动物命名和 Stroop 效应方面,年龄的主效应非常显著(P p
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Executive functioning in early and middle age adult patients operated for epidural hematoma: A comparative study.

Epidural Hematoma (EDH) is a common condition of traumatic brain injury. It has a good prognosis if prompt surgical intervention is conducted. There is a dearth of studies on neuropsychological assessment of executive functioning exclusively in post-operative EDH patients. Moreover, age as a variable in determining executive functions in patients post-head injury, has been studied mostly in the older adults. This cross-sectional case-control study assessed Executive Functions (EF) in 62 post-surgery patients with EDH and compared 57 healthy controls (HC) using standardized assessment tools of sustained attention, speed, working memory, fluency, set-shifting, perseveration, planning, and response inhibition. Further, executive functions in two phases of adulthood, viz. Early Adulthood (20-39 years) and Middle Adulthood (40-60 years) were compared in the EDH group (E-EDH and M-EDH) and HC (E-HC and M-HC). A two-way Analysis of Variance (ANOVA) and correlational analysis was conducted. Results showed a trend where the M-EDH group performed significantly poorer on executive function tests (viz a viz., time taken, errors, and correct responses), followed by E-EDH, M-HC, and E-HC. The main effect of age was found significant on Digit Symbol, Color Trail 1, N-Back 2, Animal Naming, and Stroop Effect (p < 0.01 level) while N-Back 1, WCST-PE, and Tower of London (p < 0.05 level). The findings have significant clinical and therapeutic implications. In addition, it gives guidance regarding planning specific neuropsychological tests and rehabilitation targeting specific areas of executive functions decline due to age in EDH post-surgery patients.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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