周围神经运动轴突和感觉轴突多重再生能力的差异。

Peng Jianping, Yin Xiaofeng, Wang Yanhua, Wang Zhenwei, Kou Yuhui, Xu Chungui, Zhang Peixun, Jiang Baoguo
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引用次数: 6

摘要

周围神经损伤后,轴突常从Ranvier淋巴结近端向损伤部位伸出芽。众所周知,一个母轴突可以发芽并维持几个再生轴突。如果远端残端有足够的神经内膜管供再生轴突生长,那么远端残端成熟髓鞘神经纤维的数量将大于近端残端。“多次再生”被用来描述周围神经的这种现象。根据先前的研究,含有许多轴突的突出神经可以通过从含有较少轴突的另一个神经中萌发多个再生轴突来修复。大多数周围神经包含有髓鞘的运动轴突和感觉轴突,以及无髓鞘的感觉轴突和自主轴突。本研究通过桥接腓总神经近端与腓总神经远端和胫神经,建立了腓总神经多段再生动物模型。分别在切除背根神经节(DRGs)和腹根1个月后,用组织形态学法评估运动神经和感觉神经的再生率差异。结果表明,运动神经在两个不同时间点的多次再生比明显大于感觉神经。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Different multiple regeneration capacities of motor and sensory axons in peripheral nerve.

After peripheral nerve injury, axons often project sprouts from the node of Ranvier proximal to the damage site. It is well known that one parent axon can sprout and maintain several regenerating axons. If enough endoneurial tubes in the distal stump are present for the regenerating axons to grow along, then the number of mature myelinated nerve fibers in the distal stump will be greater than the number in the proximal stump. "Multiple regeneration" is used to describe this phenomenon in the peripheral nerve. According to previous studies, a prominent nerve containing many axons can be repaired by the multiple regenerating axons sprouting from another nerve that contains fewer axons. Most peripheral nerves contain a mixture of myelinated motor and sensory axons as well as unmyelinated sensory and autonomic axons. In this study, a multiple regeneration animal model was developed by bridging the proximal common peroneal nerve with the distal common peroneal nerve and the tibial nerve. Differences in the multiple regeneration ratio of motor and sensory nerves were evaluated using histomorphometry one month after ablating the dorsal root ganglion (DRGs) and ventral roots, respectively. The results suggest that the motor nerves have a significantly larger multiple regeneration ratio than the sensory nerves at two different time points.

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