Physico-mathematics and the life sciences: experiencing the mechanism of venous return, 1650s-1680s.

ABSTRACT This article deals with physico-mathematical approaches to anatomy in post-Harveyan physiology. But rather than looking at questions of iatromechanics and animal locomotion, which often attracted this approach, I look at the problem of how blood returned to the heart – a part of the circulation today known as venous return but poorly researched in the early modern period. I follow the venous return mechanisms proposed by lesser-known authors in the mechanization of anatomy, such as Jean Pecquet (1622–1674) and Nicolaus Steno (1638–1686), alongside the more famous Giovanni Alfonso Borelli (1608–1679). Their mechanisms differed only in small details. Yet, these minor differences highlight significant aspects of the mechanization of the life sciences in the seventeenth century. First, they relied more on observations than hitherto acknowledged, even if only indirectly. Second, their mechanisms drew more from the physico-mathematical disciplines than from the trending corpuscularian philosophies of their time. Finally, these mechanisms led to a more accurate understanding of the circulation that remains valid today, thus revealing their cognitive benefits. In short, through the single problem of how blood returned to the heart, this article portrays the increasing complexity of anatomy in the early modern period.