N Voraphani, A Theamboonlers, A Khongphatthanayothin, C Srisai, Y Poovorawan
{"title":"登革病毒感染儿童肝细胞生长因子水平升高。","authors":"N Voraphani, A Theamboonlers, A Khongphatthanayothin, C Srisai, Y Poovorawan","doi":"10.1179/146532810X12786388978607","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Evidence of hepatocellular damage is common in dengue-infected individuals. Hepatocyte growth factor (HGF), a key cytokine responsible for liver regeneration, may play a prognostic role in dengue virus infection.</p><p><strong>Aim: </strong>To determine the relationship between serum HGF level and disease severity in patients with dengue virus infection.</p><p><strong>Methods: </strong>Serum samples from 27 children [17 dengue fever (DF), ten dengue haemorrhagic fever (DHF)] with serologically confirmed dengue virus infection during the febrile, toxic stages and at follow-up were analysed for HGF. Serum samples obtained from nine healthy children served as the control group.</p><p><strong>Results: </strong>In dengue-infected patients, serum HGF was significantly higher at the febrile and toxic stages than at follow-up (p<0.05). In comparison with DF, patients with DHF had a greater level of HGF at the febrile stage (p<0.05). A cut-off HGF level of 1220 pg/mL obtained during the febrile stage showed a sensitivity of 90% and a specificity of 53% for predicting clinical progression to DHF (area under the ROC curve 0.75).</p><p><strong>Conclusion: </strong>Serum HGF level at the early stage of dengue virus infection is elevated and may be a useful predictor for clinical progression to DHF.</p>","PeriodicalId":50759,"journal":{"name":"Annals of Tropical Paediatrics","volume":"30 3","pages":"213-8"},"PeriodicalIF":0.0000,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1179/146532810X12786388978607","citationCount":"13","resultStr":"{\"title\":\"Increased level of hepatocyte growth factor in children with dengue virus infection.\",\"authors\":\"N Voraphani, A Theamboonlers, A Khongphatthanayothin, C Srisai, Y Poovorawan\",\"doi\":\"10.1179/146532810X12786388978607\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Evidence of hepatocellular damage is common in dengue-infected individuals. Hepatocyte growth factor (HGF), a key cytokine responsible for liver regeneration, may play a prognostic role in dengue virus infection.</p><p><strong>Aim: </strong>To determine the relationship between serum HGF level and disease severity in patients with dengue virus infection.</p><p><strong>Methods: </strong>Serum samples from 27 children [17 dengue fever (DF), ten dengue haemorrhagic fever (DHF)] with serologically confirmed dengue virus infection during the febrile, toxic stages and at follow-up were analysed for HGF. Serum samples obtained from nine healthy children served as the control group.</p><p><strong>Results: </strong>In dengue-infected patients, serum HGF was significantly higher at the febrile and toxic stages than at follow-up (p<0.05). In comparison with DF, patients with DHF had a greater level of HGF at the febrile stage (p<0.05). A cut-off HGF level of 1220 pg/mL obtained during the febrile stage showed a sensitivity of 90% and a specificity of 53% for predicting clinical progression to DHF (area under the ROC curve 0.75).</p><p><strong>Conclusion: </strong>Serum HGF level at the early stage of dengue virus infection is elevated and may be a useful predictor for clinical progression to DHF.</p>\",\"PeriodicalId\":50759,\"journal\":{\"name\":\"Annals of Tropical Paediatrics\",\"volume\":\"30 3\",\"pages\":\"213-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1179/146532810X12786388978607\",\"citationCount\":\"13\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Tropical Paediatrics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1179/146532810X12786388978607\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Tropical Paediatrics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1179/146532810X12786388978607","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Increased level of hepatocyte growth factor in children with dengue virus infection.
Background: Evidence of hepatocellular damage is common in dengue-infected individuals. Hepatocyte growth factor (HGF), a key cytokine responsible for liver regeneration, may play a prognostic role in dengue virus infection.
Aim: To determine the relationship between serum HGF level and disease severity in patients with dengue virus infection.
Methods: Serum samples from 27 children [17 dengue fever (DF), ten dengue haemorrhagic fever (DHF)] with serologically confirmed dengue virus infection during the febrile, toxic stages and at follow-up were analysed for HGF. Serum samples obtained from nine healthy children served as the control group.
Results: In dengue-infected patients, serum HGF was significantly higher at the febrile and toxic stages than at follow-up (p<0.05). In comparison with DF, patients with DHF had a greater level of HGF at the febrile stage (p<0.05). A cut-off HGF level of 1220 pg/mL obtained during the febrile stage showed a sensitivity of 90% and a specificity of 53% for predicting clinical progression to DHF (area under the ROC curve 0.75).
Conclusion: Serum HGF level at the early stage of dengue virus infection is elevated and may be a useful predictor for clinical progression to DHF.
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