复合组织异体移植(CTA):器官还是组织移植?

IF 0.6
Karsten Knobloch, P M Vogt, H-O Rennekampff
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引用次数: 6

摘要

整形外科在移植问题上有着悠久的传统。皮肤移植是由整形外科医生帕吉特和布朗引入的。首例肾移植手术是由整形外科医生默里医生实施的。复合组织异体移植(CTA)是一个不断发展的新领域,可移植手部、带血管的膝关节或部分面部。随着欧盟指令2004/23/EC与德国组织法于2007年8月1日生效,人们对手部、手臂或面部移植的分类产生了疑问。虽然实体器官的分配是基于德国德国器官支出基金会(DSO)和欧洲移植,但组织的情况并非如此。例如,胸器官的获取是在具有既定血流动力学的心脏跳动器官供体中进行的,但组织也不是这样。考虑到手或脸作为骨骼,肌肉,神经,血管和皮肤样本的复杂性,这必须考虑到,例如,与角膜作为组织移植相比。因此,西蒙诺博士建议将面部与肾脏进行比较时,将其视为一个器官。目前,CTA的分配程序和采购问题更类似于器官移植,而不是组织移植。因此,我们认为手或部分面部的CTA与器官移植有更多的相似之处,而不仅仅是组织移植。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Composite Tissue Allotransplantation (CTA): organ or tissue transplantation?].

Plastic surgery has a long tradition in transplantation issues. Skin transplantation has been introduced by plastic surgeons Padgett and Brown. The first kidney transplantation was performed by Dr. Murray, a plastic surgeon. Composite tissue allotransplantation (CTA) is an evolving new field with transplantation of hand, vascularised knees or partial faces. With the European Union (EU) directive 2004/23/EC come into effect with the German tissue law at August 1, 2007 one has question the classification of transplantation of the hands, arms or the face as tissue or organ transplantation. While solid organs are allocated based on the German Deutsche Stiftung Organspende (DSO) and EuroTransplant, this is not the case for tissues. While for example thoracic organ procurement is performed in heart-beating organ donors with established hemodynamics, this is not the case for tissues, either. Given the complexity of a hand or a face as a sample of bones, muscles, nerves, vessels, and skin this has to be taken into account for example in comparison to a cornea as a tissue graft. As such, Dr. Siemionow has proposed a face to be regarded as an organ when comparing it to a kidney. Currently, allocation procedures as well as procurement issues in CTA are much more similar to organ- rather than tissue transplantation. Thus, we believe that CTA of hands or partial faces has more similarities to organ than to mere tissue transplantation.

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