Maria Rita Polo Gascón, Cauê Peter da Cruz Terra, Hestela de Lima Guerra, Carolina Fernandes Gualqui, Mara Cristina Souza De Lucia, Glaucia Rosana Guerra Benute, Luiz Augusto Marcondes Fonseca, Jorge Casseb, Jose Ernesto Vidal, Augusto César Penalva de Oliveira
{"title":"HIV患者认知功能障碍的患病率:垂直和水平传播。","authors":"Maria Rita Polo Gascón, Cauê Peter da Cruz Terra, Hestela de Lima Guerra, Carolina Fernandes Gualqui, Mara Cristina Souza De Lucia, Glaucia Rosana Guerra Benute, Luiz Augusto Marcondes Fonseca, Jorge Casseb, Jose Ernesto Vidal, Augusto César Penalva de Oliveira","doi":"10.1590/1980-5764-DN-2021-0023","DOIUrl":null,"url":null,"abstract":"<p><p>Antiretroviral treatment has significantly increased the survival of patients infected with HIV-1. However, with increased survival, cognitive changes associated with HIV are frequently observed in this population. The clinical manifestations of HIV changes can vary as a result of several aspects, including the virus transmission route. Several studies have pointed out premature neurological changes in vertically infected patients, while the manifestation of cognitive damage in adults may take a longer time.</p><p><strong>Objective: </strong>The aim of this study was to verify the prevalence of cognitive changes in patients with HIV via vertical transmission after the highly active antiretroviral therapy and the cognitive performance of these patients compared to a group of sexually infected patients.</p><p><strong>Methods: </strong>A total of 48 patients were evaluated, 25 with vertical transmission and 23 with sexual transmission, between May 2013 and February 2015 at the Institute of infectology Emilio Ribas. Neuropsychological tests were applied to assess cognitive performance, scales to assess symptoms of anxiety and depression, and sociodemographic questionnaire.</p><p><strong>Results: </strong>The results demonstrate that the frequency of cognitive impairment in vertically transmitted patients was higher than in sexually transmitted patients.</p><p><strong>Conclusions: </strong>These findings suggest that the deleterious effects of the HIV virus on the development of the central nervous system reverberate more strongly than in patients who acquire it after adulthood.</p>","PeriodicalId":39167,"journal":{"name":"Dementia e Neuropsychologia","volume":" ","pages":"45-51"},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170252/pdf/","citationCount":"0","resultStr":"{\"title\":\"Prevalence of cognitive impairment in HIV patients: vertical and horizontal transmission.\",\"authors\":\"Maria Rita Polo Gascón, Cauê Peter da Cruz Terra, Hestela de Lima Guerra, Carolina Fernandes Gualqui, Mara Cristina Souza De Lucia, Glaucia Rosana Guerra Benute, Luiz Augusto Marcondes Fonseca, Jorge Casseb, Jose Ernesto Vidal, Augusto César Penalva de Oliveira\",\"doi\":\"10.1590/1980-5764-DN-2021-0023\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Antiretroviral treatment has significantly increased the survival of patients infected with HIV-1. However, with increased survival, cognitive changes associated with HIV are frequently observed in this population. The clinical manifestations of HIV changes can vary as a result of several aspects, including the virus transmission route. Several studies have pointed out premature neurological changes in vertically infected patients, while the manifestation of cognitive damage in adults may take a longer time.</p><p><strong>Objective: </strong>The aim of this study was to verify the prevalence of cognitive changes in patients with HIV via vertical transmission after the highly active antiretroviral therapy and the cognitive performance of these patients compared to a group of sexually infected patients.</p><p><strong>Methods: </strong>A total of 48 patients were evaluated, 25 with vertical transmission and 23 with sexual transmission, between May 2013 and February 2015 at the Institute of infectology Emilio Ribas. Neuropsychological tests were applied to assess cognitive performance, scales to assess symptoms of anxiety and depression, and sociodemographic questionnaire.</p><p><strong>Results: </strong>The results demonstrate that the frequency of cognitive impairment in vertically transmitted patients was higher than in sexually transmitted patients.</p><p><strong>Conclusions: </strong>These findings suggest that the deleterious effects of the HIV virus on the development of the central nervous system reverberate more strongly than in patients who acquire it after adulthood.</p>\",\"PeriodicalId\":39167,\"journal\":{\"name\":\"Dementia e Neuropsychologia\",\"volume\":\" \",\"pages\":\"45-51\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170252/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dementia e Neuropsychologia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1590/1980-5764-DN-2021-0023\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dementia e Neuropsychologia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1590/1980-5764-DN-2021-0023","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Prevalence of cognitive impairment in HIV patients: vertical and horizontal transmission.
Antiretroviral treatment has significantly increased the survival of patients infected with HIV-1. However, with increased survival, cognitive changes associated with HIV are frequently observed in this population. The clinical manifestations of HIV changes can vary as a result of several aspects, including the virus transmission route. Several studies have pointed out premature neurological changes in vertically infected patients, while the manifestation of cognitive damage in adults may take a longer time.
Objective: The aim of this study was to verify the prevalence of cognitive changes in patients with HIV via vertical transmission after the highly active antiretroviral therapy and the cognitive performance of these patients compared to a group of sexually infected patients.
Methods: A total of 48 patients were evaluated, 25 with vertical transmission and 23 with sexual transmission, between May 2013 and February 2015 at the Institute of infectology Emilio Ribas. Neuropsychological tests were applied to assess cognitive performance, scales to assess symptoms of anxiety and depression, and sociodemographic questionnaire.
Results: The results demonstrate that the frequency of cognitive impairment in vertically transmitted patients was higher than in sexually transmitted patients.
Conclusions: These findings suggest that the deleterious effects of the HIV virus on the development of the central nervous system reverberate more strongly than in patients who acquire it after adulthood.
期刊介绍：
Dementia top Neuropsychologia the official scientific journal of the Cognitive Neurology and Ageing Department of the Brazilian Academy of Neurology and of the Brazilian Association of Geriatric Neuropsychiatry, is published by the "Associação Neurologia Cognitiva e do Comportamento", a nonprofit Brazilian association. Regularly published on March, June, September, and December since 2007.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
