兔克隆研究进展与展望

IF 1.2 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Cellular reprogramming Pub Date : 2022-04-01 Epub Date: 2022-02-15 DOI:10.1089/cell.2021.0090

Wenbin Cao, Jinpeng Zhao, Pengxiang Qu, Enqi Liu

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引用次数: 1

摘要

体细胞核移植(Somatic cell nuclear transfer, SCNT)在转基因动物的产生、濒危动物的保护、干细胞治疗等方面具有重要的应用价值。SCNT和基因编辑的结合产生了多种用于生命科学和医学研究的转基因动物。兔作为转基因生物反应器和人类疾病模型具有独特的优势;然而，SCNT效率低严重阻碍了该技术的应用。SCNT的困难可能是由于兔体细胞的异常重编程。本文综述了哺乳动物克隆胚胎异常重编程的研究进展，并对兔体细胞克隆的研究进展和前景进行了展望。

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Current Progress and Prospects in Rabbit Cloning.

Somatic cell nuclear transfer (SCNT) shows great value in the generation of transgenic animals, protection of endangered animals, and stem cell therapy. The combination of SCNT and gene editing has produced a variety of genetically modified animals for life science and medical research. Rabbits have unique advantages as transgenic bioreactors and human disease models; however, the low SCNT efficiency severely impedes the application of this technology. The difficulty in SCNT may be attributable to the abnormal reprogramming of somatic cells in rabbits. This review focuses on the abnormal reprogramming of cloned mammalian embryos and evaluates the progress and prospects of rabbit somatic cell cloning.

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来源期刊

Cellular reprogramming CELL & TISSUE ENGINEERING-BIOTECHNOLOGY & APPLIED MICROBIOLOGY

CiteScore

2.50

自引率

6.20%

发文量

审稿时长

3 months

期刊介绍： Cellular Reprogramming is the premier journal dedicated to providing new insights on the etiology, development, and potential treatment of various diseases through reprogramming cellular mechanisms. The Journal delivers information on cutting-edge techniques and the latest high-quality research and discoveries that are transforming biomedical research. Cellular Reprogramming coverage includes: Somatic cell nuclear transfer and reprogramming in early embryos Embryonic stem cells Nuclear transfer stem cells (stem cells derived from nuclear transfer embryos) Generation of induced pluripotent stem (iPS) cells and/or potential for cell-based therapies Epigenetics Adult stem cells and pluripotency.