Samira Behboudi-Gandevani, Mehdi Hedayati, Mohammad Ali Mansournia, Maryam Nazemipour, Maryam Rahmati, Fahimeh Ramezani Tehrani
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It is suggested that irisin, as recently described cytokine secreted by skeletal muscles and glucose-dependent insulinotropic polypeptide (GIP) as an incretin hormone that induces cytokine expression, may play key roles in favoring obesity in these women.</p><p><strong>Objectives: </strong>We aimed to evaluate the association between body mass index (BMI) and serum concentrations of irisin/GIP in women with and without PCOS in the linear and non-linear models.</p><p><strong>Methods: </strong>This cross-sectional study was conducted among 159 PCOS and 82 healthy eumenorrheic non-hirsute women aged 20 - 50 years. The fractional-polynomial model was used to develop a model of continuous risk factors, which evaluates non-linear associations between irisin/GIP and BMI among women with and without PCOS.</p><p><strong>Results: </strong>Women with PCOS were significantly younger (28.2 ± 5.8 vs. 33.0 ± 7.8 years, P < 0.001) and had a greater BMI (26.6 ± 5.2 vs. 25.2 ± 4.8 kg/m<sup>2</sup>, P = 0.04) than the healthy counterparts. There were no significant linear and non-linear associations between serum concentration of irisin/GIP and BMI in both groups. The analysis of pair-wise age and BMI matching of women with PCOS and controls confirmed these findings.</p><p><strong>Conclusions: </strong>This study showed that irisin and GIP have no association with BMI in women with or without PCOS. This finding could help to better understand the underlying pathophysiological status of PCOS, insulin resistance, and obesity-related disorders. Further large cohort studies are needed to confirm these findings.</p>","PeriodicalId":13969,"journal":{"name":"International Journal of Endocrinology and Metabolism","volume":"19 4","pages":"e111914"},"PeriodicalIF":2.1000,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/88/40/ijem-19-4-111914.PMC8761486.pdf","citationCount":"0","resultStr":"{\"title\":\"The Associations Between Serum Concentrations of Irisin and Glucose-dependent Insulinotropic Polypeptide with Body Mass Index Among Women with and Without Polycystic Ovary Syndrome.\",\"authors\":\"Samira Behboudi-Gandevani, Mehdi Hedayati, Mohammad Ali Mansournia, Maryam Nazemipour, Maryam Rahmati, Fahimeh Ramezani Tehrani\",\"doi\":\"10.5812/ijem.111914\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The actions of adipocytokines may be a connective factor between obesity and polycystic ovary syndrome (PCOS). It is suggested that irisin, as recently described cytokine secreted by skeletal muscles and glucose-dependent insulinotropic polypeptide (GIP) as an incretin hormone that induces cytokine expression, may play key roles in favoring obesity in these women.</p><p><strong>Objectives: </strong>We aimed to evaluate the association between body mass index (BMI) and serum concentrations of irisin/GIP in women with and without PCOS in the linear and non-linear models.</p><p><strong>Methods: </strong>This cross-sectional study was conducted among 159 PCOS and 82 healthy eumenorrheic non-hirsute women aged 20 - 50 years. The fractional-polynomial model was used to develop a model of continuous risk factors, which evaluates non-linear associations between irisin/GIP and BMI among women with and without PCOS.</p><p><strong>Results: </strong>Women with PCOS were significantly younger (28.2 ± 5.8 vs. 33.0 ± 7.8 years, P < 0.001) and had a greater BMI (26.6 ± 5.2 vs. 25.2 ± 4.8 kg/m<sup>2</sup>, P = 0.04) than the healthy counterparts. There were no significant linear and non-linear associations between serum concentration of irisin/GIP and BMI in both groups. The analysis of pair-wise age and BMI matching of women with PCOS and controls confirmed these findings.</p><p><strong>Conclusions: </strong>This study showed that irisin and GIP have no association with BMI in women with or without PCOS. This finding could help to better understand the underlying pathophysiological status of PCOS, insulin resistance, and obesity-related disorders. 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引用次数: 0
摘要
背景:脂肪细胞因子的作用可能是肥胖与多囊卵巢综合征(PCOS)之间的关联因素。研究表明,鸢尾素作为骨骼肌分泌的细胞因子和葡萄糖依赖型胰岛素多肽(GIP)作为一种诱导细胞因子表达的肠促胰岛素激素,可能在这些女性的肥胖中起关键作用。目的:我们的目的是在线性和非线性模型中评估患有和不患有PCOS的女性体重指数(BMI)与血清中鸢尾素/GIP浓度之间的关系。方法:对159名多囊卵巢综合征女性和82名20 ~ 50岁健康无多毛绝经期女性进行横断面研究。采用分数-多项式模型建立连续危险因素模型,评估有PCOS和无PCOS女性中鸢尾素/GIP与BMI之间的非线性关联。结果:PCOS女性明显比健康女性年轻(28.2±5.8岁比33.0±7.8岁,P < 0.001), BMI高于健康女性(26.6±5.2比25.2±4.8 kg/m2, P = 0.04)。两组患者血清中鸢尾素/GIP浓度与BMI之间均无显著的线性和非线性关联。对多囊卵巢综合征女性和对照组的年龄和BMI配对分析证实了这些发现。结论:本研究表明,鸢尾素和GIP与患有或不患有PCOS的女性的BMI无关。这一发现有助于更好地了解多囊卵巢综合征、胰岛素抵抗和肥胖相关疾病的潜在病理生理状态。需要进一步的大型队列研究来证实这些发现。
The Associations Between Serum Concentrations of Irisin and Glucose-dependent Insulinotropic Polypeptide with Body Mass Index Among Women with and Without Polycystic Ovary Syndrome.
Background: The actions of adipocytokines may be a connective factor between obesity and polycystic ovary syndrome (PCOS). It is suggested that irisin, as recently described cytokine secreted by skeletal muscles and glucose-dependent insulinotropic polypeptide (GIP) as an incretin hormone that induces cytokine expression, may play key roles in favoring obesity in these women.
Objectives: We aimed to evaluate the association between body mass index (BMI) and serum concentrations of irisin/GIP in women with and without PCOS in the linear and non-linear models.
Methods: This cross-sectional study was conducted among 159 PCOS and 82 healthy eumenorrheic non-hirsute women aged 20 - 50 years. The fractional-polynomial model was used to develop a model of continuous risk factors, which evaluates non-linear associations between irisin/GIP and BMI among women with and without PCOS.
Results: Women with PCOS were significantly younger (28.2 ± 5.8 vs. 33.0 ± 7.8 years, P < 0.001) and had a greater BMI (26.6 ± 5.2 vs. 25.2 ± 4.8 kg/m2, P = 0.04) than the healthy counterparts. There were no significant linear and non-linear associations between serum concentration of irisin/GIP and BMI in both groups. The analysis of pair-wise age and BMI matching of women with PCOS and controls confirmed these findings.
Conclusions: This study showed that irisin and GIP have no association with BMI in women with or without PCOS. This finding could help to better understand the underlying pathophysiological status of PCOS, insulin resistance, and obesity-related disorders. Further large cohort studies are needed to confirm these findings.
期刊介绍:
The aim of the International Journal of Endocrinology and Metabolism (IJEM) is to increase knowledge, stimulate research in the field of endocrinology, and promote better management of patients with endocrinological disorders. To achieve this goal, the journal publishes original research papers on human, animal and cell culture studies relevant to endocrinology.