认知障碍患者参与临床研究的意愿。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2022-03-01 Epub Date: 2022-02-11 DOI:10.3928/19404921-20220131-01
Mengchi Li, Hyejin Kim, Susan M Sereika, Trevor J Nissley, Jennifer H Lingler
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引用次数: 0

摘要

这项二次分析研究了(1)与认知障碍患者及其护理伙伴参与认知健康临床研究的意愿相关的因素,以及(2)认知障碍患者及其护理伙伴(二人组)之间在这种意愿方面的一致性。神经心理因素和参与临床研究的意愿是通过自我报告问卷收集的。参与者的社会人口学和临床信息来自匹兹堡大学阿尔茨海默病研究中心的记录。研究人员进行了二元逻辑回归和科恩卡帕系数分析。认知障碍患者对医学研究人员的信任度越高(p = 0.031,B = 0.127),认知障碍越严重(p = 0.009,B = -0.289),他们参与临床研究的意愿就越高。对于认知障碍患者参与临床研究的意愿,双方的一致程度为较差到一般(κ = 0.380)。研究结果表明,认知障碍患者如果更信任医疗专业人员,则更有可能同意参与临床研究。为认知障碍患者及其护理伙伴提供咨询的护士和其他医疗服务提供者应努力与参与者建立信任关系,并注意信任的增加会如何改变参与者与医疗专业人员之间的权力动态关系。[老年护理研究》(Research in Gerontological Nursing),15(2),76-84。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Willingness to Participate in Clinical Research Among Individuals With Cognitive Impairment.

This secondary analysis examined (1) factors associated with willingness to participate in clinical research for cognitive health among individuals with cognitive impairment and their care partners, and (2) concordance regarding such willingness between individuals with cognitive impairment and their care partners (dyads). Neuropsychological factors and willingness to participate in clinical research were collected using self-reported questionnaires. Participants' sociodemographic and clinical information was extracted from the University of Pittsburgh Alzheimer's Disease Research Center record. Binary logistic regression and Cohen's kappa coefficient analyses were performed. Greater trust in medical researchers (p = 0.031, B = 0.127) and more severe cognitive impairment (p = 0.009, B = -0.289) were associated with willingness to participate in clinical research among individuals with cognitive impairment. Dyadic agreement on willingness to have the individual with cognitive impairment enroll in clinical research was poor to fair (κ = 0.380). Findings suggest that individuals with cognitive impairment with greater trust in health professionals are more likely to agree to clinical research participation. Nurses and other health care providers who counsel individuals with cognitive impairment and their care partners should work to build trusting relationships with participants and be mindful of how increased trust can alter power dynamics between participants and health care professionals. [Research in Gerontological Nursing, 15(2), 76-84.].

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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