{"title":"一例获得性免疫缺陷综合征患者的乙基肺囊虫肺炎，表现为嗜酸性粒细胞增多和血清TARC/CCL17水平升高。","authors":"Yuki Yabuuchi, Masashi Matsuyama, Sosuke Matsumura, Masayuki Nakajima, Yoshihiko Kiyasu, Yuto Takeuchi, Yoshihiko Murata, Ryota Matsuoka, Masayuki Noguchi, Nobuyuki Hizawa","doi":"10.4081/mrm.2022.802","DOIUrl":null,"url":null,"abstract":"<p><p><i>Pneumocystis jirovecii</i> pneumonia (PCP) in patients with acquired immune deficiency syndrome (AIDS) shows eosinophilic pneumonia like condition. The detailed mechanisms how AIDS-associated PCP causes eosinophilic pneumonia has not been elucidated, but it has been suggested that beta-D-glucan, a major component of <i>Pneumocystis jirovecii</i>, and T helper type 2 immunity may be involved in the mechanism of eosinophilia in the lung. We experienced the case who developed an eosinophilic pneumonia-like condition in a patient with AIDS-associated PCP, whose clinical course indicated the importance of TARC/CCL17 but not IL-4 and IL-5 as involved in eosinophilia caused by HIV and <i>Pneumocystis jirovecii</i> infection.</p>","PeriodicalId":51135,"journal":{"name":"Multidisciplinary Respiratory Medicine","volume":"17 2","pages":"802"},"PeriodicalIF":2.0000,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9c/02/mrm-17-2-802.PMC8764545.pdf","citationCount":"1","resultStr":"{\"title\":\"A case of <i>Pneumocystis jirovecii</i> pneumonia in a patient with acquired immune deficiency syndrome who showed eosinophilia and an increased serum TARC/CCL17 level.\",\"authors\":\"Yuki Yabuuchi, Masashi Matsuyama, Sosuke Matsumura, Masayuki Nakajima, Yoshihiko Kiyasu, Yuto Takeuchi, Yoshihiko Murata, Ryota Matsuoka, Masayuki Noguchi, Nobuyuki Hizawa\",\"doi\":\"10.4081/mrm.2022.802\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Pneumocystis jirovecii</i> pneumonia (PCP) in patients with acquired immune deficiency syndrome (AIDS) shows eosinophilic pneumonia like condition. The detailed mechanisms how AIDS-associated PCP causes eosinophilic pneumonia has not been elucidated, but it has been suggested that beta-D-glucan, a major component of <i>Pneumocystis jirovecii</i>, and T helper type 2 immunity may be involved in the mechanism of eosinophilia in the lung. We experienced the case who developed an eosinophilic pneumonia-like condition in a patient with AIDS-associated PCP, whose clinical course indicated the importance of TARC/CCL17 but not IL-4 and IL-5 as involved in eosinophilia caused by HIV and <i>Pneumocystis jirovecii</i> infection.</p>\",\"PeriodicalId\":51135,\"journal\":{\"name\":\"Multidisciplinary Respiratory Medicine\",\"volume\":\"17 2\",\"pages\":\"802\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2022-01-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9c/02/mrm-17-2-802.PMC8764545.pdf\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Multidisciplinary Respiratory Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4081/mrm.2022.802\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Multidisciplinary Respiratory Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4081/mrm.2022.802","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 1
摘要
获得性免疫缺陷综合征(AIDS)患者的乙基肺囊虫肺炎(PCP)表现为嗜酸性肺炎样症状。艾滋病相关PCP引起嗜酸性粒细胞肺炎的详细机制尚未阐明，但有研究表明，乙型肺囊虫的主要成分β - d -葡聚糖和T辅助2型免疫可能参与了肺嗜酸性粒细胞增多的机制。我们经历了一个艾滋病相关PCP患者出现嗜酸性肺炎样疾病的病例，其临床病程表明TARC/CCL17而不是IL-4和IL-5在HIV和乙氏肺囊虫感染引起的嗜酸性粒细胞增多症中的重要性。
A case of Pneumocystis jirovecii pneumonia in a patient with acquired immune deficiency syndrome who showed eosinophilia and an increased serum TARC/CCL17 level.
Pneumocystis jirovecii pneumonia (PCP) in patients with acquired immune deficiency syndrome (AIDS) shows eosinophilic pneumonia like condition. The detailed mechanisms how AIDS-associated PCP causes eosinophilic pneumonia has not been elucidated, but it has been suggested that beta-D-glucan, a major component of Pneumocystis jirovecii, and T helper type 2 immunity may be involved in the mechanism of eosinophilia in the lung. We experienced the case who developed an eosinophilic pneumonia-like condition in a patient with AIDS-associated PCP, whose clinical course indicated the importance of TARC/CCL17 but not IL-4 and IL-5 as involved in eosinophilia caused by HIV and Pneumocystis jirovecii infection.
期刊介绍：
Multidisciplinary Respiratory Medicine is the official journal of the Italian Respiratory Society - Società Italiana di Pneumologia (IRS/SIP). The journal publishes on all aspects of respiratory medicine and related fields, with a particular focus on interdisciplinary and translational research.
The interdisciplinary nature of the journal provides a unique opportunity for researchers, clinicians and healthcare professionals across specialties to collaborate and exchange information. The journal provides a high visibility platform for the publication and dissemination of top quality original scientific articles, reviews and important position papers documenting clinical and experimental advances.
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