In health and disease – microRNA in skeletal muscles function

MicroRNAs (miRNAs), although do not encode proteins, they are involved in many biological processes. Here we focus on their role in skeletal muscle development and function. In health, they play an important role during skeletal muscle regeneration by regulating satellite cells quiescence, activation, proliferation, differentiation into myoblasts, and finally formation of myotubes. Moreover, miRNAs play a role in muscles disease development. For this reason, they can be used as disease biomarkers or potential therapeutic targets. Moreover, physical activity also influences the changes in miRNA expression. Certain types of exercises, their duration, and intensity differently impact the expression of many miRNAs.