Yasemin Oram, A Deniz Akkaya, Ethem Güneren, Gürsel Turgut
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A novel autologous dermal filler based on cultured fibroblasts and plasma gel for facial wrinkles: Long term results.
Autologous cultured fibroblasts combined with plasma gel (FibrogelTM) can be used as an injectable autologous soft tissue filler. Herein, we report the assessment of the long-term clinical efficacy and safety of Fibrogel for facial wrinkles. Ten healthy adults were treated for facial wrinkles with Fibrogel, an innovative autologous filler. Patients underwent three treatment sessions at 1-month intervals for the correction of infraorbital, nasolabial, and marionette folds. In each session, 6-8 mL of Fibrogel filler containing 4 million fibroblasts/mL, was injected into the deep dermis or subdermal plane. Three evaluators independently assessed the efficacy at 3, 6 and 12 months after the last treatment, using the validated Global Esthetic Improvement Scale at two different times in a blinded manner. Infraorbital area and lower face were evaluated separately. All patients showed immediate improvement after the first injection at the infraorbital area and lower face. Follow-ups at 3, 6 and 12 months revealed that the improvement was persistent. Adverse reactions were mild and the treatment was well tolerated. Delivering autologous cultured fibroblasts embedded in an autologous plasma gel (Fibrogel) to the skin can provide immediate volume effect and long-term improvement. Therefore, Fibrogel can be considered as a promising novel autologous filler.
期刊介绍:
A unique journal that focuses on the application of cosmetic laser and light therapies on the skin. The Journal of Cosmetic & Laser Therapy provides a forum for stimulating and up-to-date studies demonstrating the wide range of therapeutic options for clinicians and surgeons involved in cosmetic and dermatological treatment.
The journal is aimed at dermatologists, cosmetic surgeons, plastic and facial plastic surgeons, oculoplastic surgeons and all those interested in the rapidly expanding field of cosmetic and laser therapy.
Features include:
-Cosmetic surgery, including facial rejuvenation, hair removal and skin resurfacing
-Use of lasers and other light sources for cosmetic and dermatological treatment
-Applications of peeling agents, fillers, injectables, implants and other cosmetic modalities
-Topical treatments
-Practical tips and safety issues