骨髓增殖性肿瘤的血栓和出血:血小板的观点。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
ACS Applied Bio Materials Pub Date : 2022-10-03 Epub Date: 2022-01-27 DOI:10.1080/09537104.2021.2019210
Yiming Feng, Yue Zhang, Jialan Shi
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引用次数: 1

摘要

经典骨髓增生性肿瘤(classic myeleloprolifative neoplasm, MPN)又称bcr - abl阴性MPN,是一种以造血干细胞异常扩增为特征的克隆性疾病。已经证明,与一般人群相比,MPN患者更容易发生血栓事件。因此,研究人员一直在探索MPN血栓的治疗方法。然而,抗血栓治疗为MPN的临床管理带来了另一个问题,因为它们可能导致出血事件。当血栓和出血这两种看似矛盾的并发症同时发生在MPN患者身上时,会导致更严重的后果。因此,如何在达到最佳抗栓效果的同时最大限度地减少出血事件是一个重大挑战。迄今为止,还没有一个完美的策略来应对这一挑战,因此需要建立一种新的治疗方法。在本文中,我们首次从血小板的角度描述了MPN中血栓和出血事件的机制。基于血小板在MPN中的双重作用,通过调整抗血小板药物的给药时间和剂量,可以制定出同时控制血栓和出血的最佳抗血栓治疗策略。我们认为,未来应更多地关注血小板在MPN血栓形成和MPN出血中的关键作用,以便更好地管理MPN中的不良血管事件。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Thrombosis and hemorrhage in myeloproliferative neoplasms: The platelet perspective.

Classical myeloproliferative neoplasm (MPN), also known as BCR-ABL-negative MPN, is a clonal disease characterized by abnormal expansion of hematopoietic stem cells. It has been demonstrated that MPN patients are more susceptible to thrombotic events compared to the general population. Therefore, researchers have been exploring the treatment for MPN thrombosis. However, antithrombotic therapies have brought another concern for the clinical management of MPN because they may cause bleeding events. When thrombosis and bleeding, two seemingly contradictory complications, occur in MPN patients at the same time, they will lead to more serious consequences. Therefore, it is a major challenge to achieving the best antithrombotic effect and minimizing bleeding events simultaneously. To date, there has yet been a perfect strategy to meet this challenge and therefore a new treatment method needs to be established. In this article, we describe the mechanism of thrombosis and bleeding events in MPN from the perspective of platelets for the first time. Based on the double-sided role of platelets in MPN, optimal antithrombotic treatment strategies that can simultaneously control thrombosis and bleeding at the same time may be formulated by adjusting the administration time and dosage of antiplatelet drugs. We argue that more attention should be paid to the critical role of platelets in MPN thrombosis and MPN bleeding in the future, so as to better manage adverse vascular events in MPN.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
期刊介绍: ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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