Emilija Atanasovska, Marija Petrusevska, Dragica Zendelovska, Katerina Spasovska, Milena Stevanovikj, Katerina Kasapinova, Kalina Gjorgjievska, Nikola Labachevski
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引用次数: 12
摘要
背景:COVID-19以氧化应激的存在为特征。维生素D水平被认为是影响疾病严重程度的因素之一。本研究的目的是评估住院COVID-19患者血清维生素D水平、氧化应激标志物与疾病严重程度之间的关系。方法:测定33例COVID-19患者的维生素D水平。测定血清总抗氧化能力和血浆过氧化物。结果:COVID-19重症患者的维生素D水平较低(18.39±2.29 ng/mL vs. 28.47±3.05 ng/mL, p p p)。结论:本研究数据证明维生素D是通过其抗炎和抗氧化作用改善疾病严重程度的重要因素。
Vitamin D levels and oxidative stress markers in patients hospitalized with COVID-19.
Background: COVID-19 is characterized by the presence of oxidative stress. Vitamin D status has been reviewed as one of the factors that may affect disease severity. The aim of this study was to assess the relationship between serum vitamin D levels, oxidative stress markers and disease severity in hospitalized COVID-19 patients.
Methods: Vitamin D levels were measured in 33 patients with COVID-19. The total antioxidant power and plasma peroxides were determined in serum.
Results: Severe COVID-19 patients have lower vitamin D levels (18.39 ± 2.29 ng/mL vs. 28.47 ± 3.05 ng/mL, p < .05) and higher oxidative stress compared to the moderate group. When divided according to serum vitamin D levels, significantly higher values of LDH (604.8 ± 76.98 IU/mL vs. 261.57 ± 47.33 IU/mL) and D-dimer (5978 ± 2028ng/mL vs. 977.7 ± 172 ng/mL) were obtained in the group with vitamin D below 30 ng/mL, followed with significantly higher levels of plasma peroxides (d-ROMs: 414.9 ± 15.82 U.Carr vs. 352.4 ± 18.77 U.Carr; p < .05) and oxidative stress index (OSI: 92.25 ± 6.60 vs. 51.89 ± 6.45; p < .001).
Conclusion: The presented data provide a justification to consider vitamin D as an important factor that could ameliorate disease severity through its anti-inflammatory and antioxidant effects.
期刊介绍：
Redox Report is a multidisciplinary peer-reviewed open access journal focusing on the role of free radicals, oxidative stress, activated oxygen, perioxidative and redox processes, primarily in the human environment and human pathology. Relevant papers on the animal and plant environment, biology and pathology will also be included.
While emphasis is placed upon methodological and intellectual advances underpinned by new data, the journal offers scope for review, hypotheses, critiques and other forms of discussion.
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