{"title":"[好的突变克隆消除新生肿瘤]。","authors":"Bertrand Jordan","doi":"10.1051/medsci/2021239","DOIUrl":null,"url":null,"abstract":"<p><p>Most (>90%) of the nascent tumours present in murine oesophageal epithelium after mutagen treatment disappear during the following months. This elimination is driven by mutant (but phenotypically normal) clones that gradually outcompete and eliminate the neoplastic clones. This novel mechanism, demonstrated in the mouse, is probably active in humans as well and may have important clinical implications.</p>","PeriodicalId":519512,"journal":{"name":"Medecine sciences : M/S","volume":"38 1","pages":"101-106"},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Good mutant clones eliminate nascent tumours].\",\"authors\":\"Bertrand Jordan\",\"doi\":\"10.1051/medsci/2021239\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Most (>90%) of the nascent tumours present in murine oesophageal epithelium after mutagen treatment disappear during the following months. This elimination is driven by mutant (but phenotypically normal) clones that gradually outcompete and eliminate the neoplastic clones. This novel mechanism, demonstrated in the mouse, is probably active in humans as well and may have important clinical implications.</p>\",\"PeriodicalId\":519512,\"journal\":{\"name\":\"Medecine sciences : M/S\",\"volume\":\"38 1\",\"pages\":\"101-106\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medecine sciences : M/S\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1051/medsci/2021239\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/21 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medecine sciences : M/S","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1051/medsci/2021239","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/21 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Most (>90%) of the nascent tumours present in murine oesophageal epithelium after mutagen treatment disappear during the following months. This elimination is driven by mutant (but phenotypically normal) clones that gradually outcompete and eliminate the neoplastic clones. This novel mechanism, demonstrated in the mouse, is probably active in humans as well and may have important clinical implications.
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