Association of human Hedgehog interacting protein gene polymorphisms with the risk of chronic obstructive pulmonary disease: a meta-analysis.

Objective: To date, some studies revealed that HHIP gene polymorphisms may be associated with the risk of chronic obstructive pulmonary disease (COPD). Therefore, this meta-analysis explored the association between single-nucleotide polymorphisms (SNPs) of the human hedgehog interacting protein (HHIP) gene and susceptibility to COPD.

Methods: Seven Chinese and English electronic databases were searched for eligible studies up to 30 May 2020. After the inclusion criteria were strictly followed, the Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of the included studies. The pooled odds ratio (OR) of the 95% confidence interval (CI) under four different genetic models was calculated to evaluate the association strength between the SNPs and COPD. Egger's test was used to evaluate publication bias.

Results: This meta-analysis was registered at PROSPERO (CRD42021235708). In total, 12 studies involving 6623 COPD patients and 11,373 healthy controls were included. Regarding rs13118928 and rs1828591, an A > G mutation increased the risk of COPD in Asian and Caucasian individuals, and the rs13147758 A > G mutation and rs10519717 C > T mutation increased the risk of COPD only in Asian people. No significant publication bias was observed.

Conclusion: This meta-analysis provides a theoretical basis suggesting that HHIP gene polymorphisms may be associated with the risk of COPD.